HCSGD entry for CD14

1. General information

Official gene symbolCD14
Entrez ID929
Gene full nameCD14 molecule
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001530Lipopolysaccharide bindingIDAmolecular_function
GO:0001847Opsonin receptor activityTASmolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0006909PhagocytosisTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0009408Response to heatIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010008Endosome membraneTAScellular_component
GO:0016019Peptidoglycan receptor activityTASmolecular_function
GO:0031225Anchored component of membraneIEAcellular_component
GO:0032026Response to magnesium ionIEAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIDAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034612Response to tumor necrosis factorIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045471Response to ethanolIEAbiological_process
GO:0045807Positive regulation of endocytosisIEAbiological_process
GO:0050715Positive regulation of cytokine secretionIEAbiological_process
GO:0070891Lipoteichoic acid bindingIDAmolecular_function
GO:0071222Cellular response to lipopolysaccharideIDA IEAbiological_process
GO:0071223Cellular response to lipoteichoic acidIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03590276210.49330431970.43165363311.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2436814538
GSE13712_SHEARDown-1.2615820946
GSE13712_STATICUp0.0313447367
GSE19018Up0.0131300212
GSE19899_A1Down-0.0918421501
GSE19899_A2Up0.3779773708
PubMed_21979375_A1Up0.1054860127
PubMed_21979375_A2Down-0.0344883903
GSE35957Up2.2020249239
GSE36640Up0.4066079434
GSE54402Down-0.0318315992
GSE9593Up1.0537337321
GSE43922Up0.0358261604
GSE24585Up0.0790607154
GSE37065Up0.3228252433
GSE28863_A1Up0.4481286998
GSE28863_A2Up0.4980395254
GSE28863_A3Down-0.0078854802
GSE28863_A4Down-0.0811552368
GSE48662Up0.4712199758

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016817MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 9 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27073222RESULTS: Cases had lower CD4(+) T-cell counts, higher CD8(+) T-cell counts, and increased levels of immune activation (ie, increased soluble CD14 [sCD14] level and increased percentages of CD38(+)HLA-DR(+) cells among both CD4(+) and CD8(+) T cells), regulatory T cells, and percentage of programmed cell death 1 (PD-1)-expressing cells among CD4(+) T cells
27073222The increased soluble CD14 levels and percentage of CD38(+)HLA-DR(+) cells among CD4(+) T cells correlated with shorter telomeres and increased regulatory T-cell levels
26196672CD14 was expressed at low levels on OK3 and OK3H and HLA-DR on BMA13 (84
25604328Immunosenescence was investigated by analysing CD57(+) CD28(-) levels, immune activation by analysing CD38(+) HLA-DR(+) levels, inflammation by analysing interleukin (IL)-6 levels, and microbial translocation by analysing lipopolysaccharide (LPS) and soluble CD14 (sCD14) levels
23974111Erlotinib and gefitinib alone did not promote differentiation, yet stimulated the acquisition of morphological and biochemical maturation markers (including the expression of CD11b and CD14 as well as increased NADPH oxidase activity) when combined with either ATRA or VD
22948867MVC-specific effects in patients with virological responses included increased CD8(+) T-cell activation and senescence levels, preservation of an increase in soluble CD14 (sCD14), and a decrease in D dimer levels
17951672Surface markers that can be used to characterize FLS include positive staining for VCAM-1, CD44, CD55, CD90 (Thy-1), and cadherin-11, coupled with the absence of macrophage markers such as CD14 or CD68
16955214Enforced stable over-expression of CLU in K562 cells inhibited the expression of the CD14 differentiation marker and blocked differentiation to either monocytes/megacaryoblasts or to erythrocytes
15685514Expression of p53, CD14/CD16, and intracellular cytokine production (interleukin-1beta [IL-1beta], IL-6, and IL-4) was evaluated by means of flow cytometry using specific antibodies
12803109RESULTS: L-C increases HLA-DR and CD14 surface antigens, while morphologic and marker analysis of the treated cells reveals the presence of monocytes, neutrophiles and few dendritic cells
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