HCSGD entry for MED14
1. General information
| Official gene symbol | MED14 |
|---|---|
| Entrez ID | 9282 |
| Gene full name | mediator complex subunit 14 |
| Other gene symbols | CRSP150 CRSP2 CSRP CXorf4 DRIP150 EXLM1 RGR1 TRAP170 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001104 | RNA polymerase II transcription cofactor activity | IDA | molecular_function |
| GO:0003712 | Transcription cofactor activity | IDA | molecular_function |
| GO:0003713 | Transcription coactivator activity | IDA | molecular_function |
| GO:0004872 | Receptor activity | IDA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | IDA TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016592 | Mediator complex | IDA | cellular_component |
| GO:0019827 | Stem cell maintenance | IEA | biological_process |
| GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | NAS | molecular_function |
| GO:0030518 | Intracellular steroid hormone receptor signaling pathway | IDA | biological_process |
| GO:0030521 | Androgen receptor signaling pathway | IDA | biological_process |
| GO:0042809 | Vitamin D receptor binding | NAS | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046966 | Thyroid hormone receptor binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7287248585 | 0.2884496676 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3084531343 |
| GSE13712_SHEAR | Up | 0.1016088981 |
| GSE13712_STATIC | Up | 0.1159247022 |
| GSE19018 | Up | 0.0476178246 |
| GSE19899_A1 | Up | 0.0183140835 |
| GSE19899_A2 | Down | -0.1289420275 |
| PubMed_21979375_A1 | Up | 0.0707195871 |
| PubMed_21979375_A2 | Up | 0.1081184538 |
| GSE35957 | Down | -0.1399009218 |
| GSE36640 | Down | -0.1515104771 |
| GSE54402 | Down | -0.1004549037 |
| GSE9593 | Down | -0.2014875417 |
| GSE43922 | Down | -0.0501040426 |
| GSE24585 | Down | -0.3286726177 |
| GSE37065 | Down | -0.0693689635 |
| GSE28863_A1 | Up | 0.5873117749 |
| GSE28863_A2 | Up | 0.4315529017 |
| GSE28863_A3 | Down | -0.5007835231 |
| GSE28863_A4 | Up | 0.0374112170 |
| GSE48662 | Up | 0.1213532859 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-532-3p | MIMAT0004780 | MIRT037921 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047245 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052118 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
