HCSGD entry for MAPKAPK2
1. General information
| Official gene symbol | MAPKAPK2 |
|---|---|
| Entrez ID | 9261 |
| Gene full name | mitogen-activated protein kinase-activated protein kinase 2 |
| Other gene symbols | MAPKAP-K2 MK-2 MK2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | biological_process |
| GO:0000187 | Activation of MAPK activity | TAS | biological_process |
| GO:0002224 | Toll-like receptor signaling pathway | ISS TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004871 | Signal transducer activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0006691 | Leukotriene metabolic process | TAS | biological_process |
| GO:0006950 | Response to stress | IDA | biological_process |
| GO:0006954 | Inflammatory response | ISS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IMP | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0018105 | Peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0019369 | Arachidonic acid metabolic process | TAS | biological_process |
| GO:0031572 | G2 DNA damage checkpoint | IMP | biological_process |
| GO:0032496 | Response to lipopolysaccharide | ISS | biological_process |
| GO:0032675 | Regulation of interleukin-6 production | ISS | biological_process |
| GO:0032680 | Regulation of tumor necrosis factor production | IDA | biological_process |
| GO:0034097 | Response to cytokine | IDA | biological_process |
| GO:0034134 | Toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0034138 | Toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0034146 | Toll-like receptor 5 signaling pathway | TAS | biological_process |
| GO:0034162 | Toll-like receptor 9 signaling pathway | TAS | biological_process |
| GO:0034166 | Toll-like receptor 10 signaling pathway | TAS | biological_process |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0035924 | Cellular response to vascular endothelial growth factor stimulus | IMP | biological_process |
| GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | TAS | biological_process |
| GO:0038124 | Toll-like receptor TLR6:TLR2 signaling pathway | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0044351 | Macropinocytosis | ISS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0048010 | Vascular endothelial growth factor receptor signaling pathway | IMP | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048839 | Inner ear development | IEA | biological_process |
| GO:0051403 | Stress-activated MAPK cascade | TAS | biological_process |
| GO:0070935 | 3'-UTR-mediated mRNA stabilization | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3991679343 | 0.4133874511 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0361250575 |
| GSE13712_SHEAR | Down | -0.4110437301 |
| GSE13712_STATIC | Down | -0.1089420414 |
| GSE19018 | Up | 0.0998794623 |
| GSE19899_A1 | Down | -0.1367819713 |
| GSE19899_A2 | Up | 0.3006381050 |
| PubMed_21979375_A1 | Up | 0.7320061235 |
| PubMed_21979375_A2 | Down | -0.2277941951 |
| GSE35957 | Down | -0.1490931211 |
| GSE36640 | Down | -0.1251076483 |
| GSE54402 | Up | 0.3464616467 |
| GSE9593 | Up | 0.0630826711 |
| GSE43922 | Up | 0.0209478096 |
| GSE24585 | Down | -0.1192950098 |
| GSE37065 | Up | 0.0247776475 |
| GSE28863_A1 | Up | 0.0826388879 |
| GSE28863_A2 | Up | 0.4756208473 |
| GSE28863_A3 | Down | -0.2067592177 |
| GSE28863_A4 | Down | -0.2015166828 |
| GSE48662 | Up | 0.0773080546 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Staurosporine | DB02010 | EXPT02970 | EXPT02972 |
| 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione | DB07234 | - |
| (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE | DB07406 | - |
| (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one | DB07430 | - |
| (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one | DB07431 | - |
| 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | DB07728 | - |
| 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | DB08358 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022202 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036373 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040005 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041511 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043144 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26280535 | In turn, MAPKAPK2 phosphorylates the RNA-binding protein ZFP36L1 during senescence, inhibiting its ability to degrade the transcripts of numerous SASP components |
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