HCSGD entry for RPS6KA5

1. General information

Official gene symbolRPS6KA5
Entrez ID9252
Gene full nameribosomal protein S6 kinase, 90kDa, polypeptide 5
Other gene symbolsMSK1 MSPK1 RLPK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0001818Negative regulation of cytokine productionTASbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIDA IEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusIDA IEA IMPcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005840RibosomeIEAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIDA IEA IMPbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0016572Histone phosphorylationIDA TASbiological_process
GO:0032793Positive regulation of CREB transcription factor activityTASbiological_process
GO:0033129Positive regulation of histone phosphorylationIMPbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035066Positive regulation of histone acetylationIMPbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043987Histone H3-S10 phosphorylationIMPbiological_process
GO:0043988Histone H3-S28 phosphorylationIMPbiological_process
GO:0043990Histone H2A-S1 phosphorylationIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0070498Interleukin-1-mediated signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.32219290680.42922580450.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1043663303
GSE13712_SHEARDown-0.5129194240
GSE13712_STATICDown-0.8005981917
GSE19018Up0.1140541658
GSE19899_A1Up0.1402709910
GSE19899_A2Down-0.3061756694
PubMed_21979375_A1Up0.0336730880
PubMed_21979375_A2Down-0.2260159379
GSE35957Down-0.6454952552
GSE36640Down-0.2298257933
GSE54402Up0.2542272086
GSE9593Up0.0128867774
GSE43922Up0.0069805863
GSE24585Up0.3339387608
GSE37065Up0.5246984852
GSE28863_A1Up0.2184367019
GSE28863_A2Up0.3923155480
GSE28863_A3Up0.1471023332
GSE28863_A4Up0.0944307685
GSE48662Up0.2783903215

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148a-3pMIMAT0000243MIRT004504qRT-PCR//Luciferase reporter assay//Western blot//Reporter assayFunctional MTI20406806
hsa-miR-128-3pMIMAT0000424MIRT022082SequencingFunctional MTI (Weak)20371350
hsa-miR-101-3pMIMAT0000099MIRT027312SequencingFunctional MTI (Weak)20371350
hsa-miR-27a-3pMIMAT0000084MIRT028694SequencingFunctional MTI (Weak)20371350
hsa-miR-744-5pMIMAT0004945MIRT037609CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048811CLASHFunctional MTI (Weak)23622248
hsa-miR-19a-3pMIMAT0000073MIRT050647CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-148a-3pMIMAT0000243NAhsa-miR-148a{Western blot}{overexpression by miRNA precursor transfection}20406806
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.