HCSGD entry for CD8A
1. General information
| Official gene symbol | CD8A |
|---|---|
| Entrez ID | 925 |
| Gene full name | CD8a molecule |
| Other gene symbols | CD8 Leu2 MAL p32 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002456 | T cell mediated immunity | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | NAS | cellular_component |
| GO:0006955 | Immune response | NAS | biological_process |
| GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | NAS | biological_process |
| GO:0009897 | External side of plasma membrane | IDA | cellular_component |
| GO:0015026 | Coreceptor activity | NAS | molecular_function |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019882 | Antigen processing and presentation | NAS | biological_process |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0042101 | T cell receptor complex | NAS | cellular_component |
| GO:0042110 | T cell activation | NAS | biological_process |
| GO:0042288 | MHC class I protein binding | NAS | molecular_function |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0045065 | Cytotoxic T cell differentiation | IEA | biological_process |
| GO:0050776 | Regulation of immune response | TAS | biological_process |
| GO:0050850 | Positive regulation of calcium-mediated signaling | IEA | biological_process |
| GO:0051607 | Defense response to virus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5581796056 | 0.7873776148 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0380782504 |
| GSE13712_SHEAR | Down | -0.2888695399 |
| GSE13712_STATIC | Up | 0.1745734970 |
| GSE19018 | Up | 0.2201199339 |
| GSE19899_A1 | Up | 0.0111797106 |
| GSE19899_A2 | Down | -0.1315415945 |
| PubMed_21979375_A1 | Up | 0.0469323878 |
| PubMed_21979375_A2 | Down | -0.2252238434 |
| GSE35957 | Up | 0.1430623805 |
| GSE36640 | Down | -0.2188492147 |
| GSE54402 | Up | 0.0181481381 |
| GSE9593 | Down | -0.1259313301 |
| GSE43922 | Up | 0.2882415813 |
| GSE24585 | Up | 0.1981719641 |
| GSE37065 | Down | -0.0657881448 |
| GSE28863_A1 | Up | 0.0001917346 |
| GSE28863_A2 | Up | 0.0615265559 |
| GSE28863_A3 | Up | 0.2095316990 |
| GSE28863_A4 | Up | 0.0335605854 |
| GSE48662 | Up | 0.0654227395 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-196b-5p | MIMAT0001080 | MIRT007284 | Luciferase reporter assay | Functional MTI | 23359619 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT016928 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 39 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 28066427 | Although the mechanisms underlying steroid resistance in these lymphocytes is largely unknown, new research has identified a role for cytotoxic pro-inflammatory CD8+ T-cells and CD8+ natural killer T-like (NKT-like) cells |
| 27354367 | Markers of CD4(+) T-cell senescence (ie, the percentage of CD28(-)CD57(+) cells among CD4(+) T cells ) and CD4(+)/CD8(+) T-cell exhaustion (ie, the percentage of PD-1(+) cells among CD4(+)/CD8(+) T cells) decreased after ART |
| 26990630 | T-cell receptor rearrangement excision circle levels and CD8 recent thymic emigrant cells (CD45RACD31) were significantly lower in the HIV+ than in control groups (overall, P = 0 |
| 26914971 | The number of CD8(+) memory T cells increased in both groups (p < 0 |
| 26914971 | In the infection group, the CD8(+) CD28(null) T cell percentage increased between 3 and 6 mo (p = 0 |
| 26711627 | RESULTS: The differences between patients and controls, and the changes in the frequency of CD8+ T-cell subpopulations among lung cancer patients corresponded to those seen in immunosenescence: lower CD8-/CD8+ ratio, lower proportions of CD28+CD57- cells consisting of naive and central memory cells, and higher proportions of senescent-enriched CD28-CD57+ cells among the lung cancer patients, with the stage IV lung cancer patients showing the most pronounced changes |
| 26360056 | Unsupervised clustering of the miRNA expression data revealed an age-related clustering in the CD45RO- T cells, while CD45RO+ T cells clustered based on expression of CD4 and CD8 |
| 26277688 | Aging-associated subpopulations of human CD8+ T-lymphocytes identified by their CD28 and CD57 phenotypes |
| 26277688 | CONCLUSION: Among CD8+ T-lymphocytes, CD28+CD57+ cells represent a subset with some senescent features that are distinct from the CD28-CD57+ cells |
| 26272362 | Immunohistochemistry was used to evaluate the expression of CXCL16/CXCR6, CD3(+) T cells (CD4(+), CD8(+)), and CD20(+) B cells |
| 25750301 | Among the T-cells, there was a lower CD8-/CD8+ ratio, persisting over the six months, in patients with cancer compared to controls |
| 25732234 | Finally, for the first time, we examined the so-called TSCM cell (T-stem cell-like memory) subpopulations in both CD4(+) and CD8(+) subsets and found that neither CMV-seropositivity nor age or sex affected their frequencies |
| 25535858 | To better clarify these associations, we investigated the relationships of global sleep quality, measured by the Pittsburgh Sleep Quality Index (PSQI), and diary-reported sleep duration with telomere length in different immune cell subsets, including granulocytes, peripheral blood mononuclear cells (PBMCs), CD8+ and CD4+ T lymphocytes, and B lymphocytes in a sample of 87 obese men and women (BMI mean=35 |
| 24231352 | Peripheral blood CD8+ T lymphocytes collected from healthy donors displayed an age-dependent accumulation of senescent cells (CD28-CD57+) with decreased Delta133p53 and increased p53beta expression |
| 24231352 | Human lung tumor-associated CD8+ T lymphocytes also harbored senescent cells |
| 24231352 | Cultured CD8+ blood T lymphocytes underwent replicative senescence that was associated with loss of CD28 and Delta133p53 protein |
| 24185682 | CCR2 or CX3CR1-expressing cells were characterized by double immunofluorescence with CD3, CD4, CD8, CD56 or CD68 |
| 24185682 | Most CX3CR1-expressing inflammatory cells were CD3-positive T cells (CD8 > CD4) |
| 23962178 | Moreover, increased T cell differentiation was observed with higher percentages of CD57+ and CD28null CD4+ and CD8+ memory T cells |
| 23686519 | CD8+ and CD4+ T cells were screened for novel receptors, and where indicated, bioassays were performed to determine the functional relevance of the identified receptor |
| 22663935 | Limited evidence was found for immunosenescence in frailty; although total lymphocyte count was inversely related, no association was found with the immune risk profile and the inverse associations observed with memory/naive CD8 T and B cell ratios were in the opposite direction to that expected |
| 22613541 | The inappropriate age-dependent trajectory of CD28(-)/CD8(+) and CD95(-)/CD8(+) by age, which suggested 85 might be an inflexion point of age during T-cell ageing, warrants further exploration of the underlying mechanisms of T-cell ageing |
| 22396780 | Instead a set of surface markers including IL-7Ralpha and KLRG1 is commonly used to predict the potential of CD8 effector T cells to differentiate into memory cells |
| 22092365 | The proportion of apoptotic cells within the CD8(+) fraction was higher in patients compared with controls and was correlated with the percentage of Ki-67(+) cells, indicating an activation-induced accelerated CD8(+) cell death |
| 21635686 | One of the most prominent changes during T-cell aging in humans is the accumulation of CD28(null) T cells, mainly CD8+ and also CD4+ T cells |
| 19032694 | We have recently shown in non-human primates that caloric restriction (CR) initiated during adulthood can delay T-cell aging and preserve naive CD8 and CD4 T cells into advanced age |
| 18981163 | Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes |
| 18981163 | Nevertheless, during aging and chronic HIV-1 infection, there are high proportions of dysfunctional CD8(+) CTL with short telomeres, suggesting that telomerase is limiting |
| 18981163 | The present study shows that exposure of CD8(+) T lymphocytes from HIV-infected human donors to a small molecule telomerase activator (TAT2) modestly retards telomere shortening, increases proliferative potential, and, importantly, enhances cytokine/chemokine production and antiviral activity |
| 18220835 | CD8(+) cytotoxic lymphocytes |
| 17379755 | Blood lymphocytes isolated before, immediately after, and 1 h after exercise were assessed for cell surface expression of KLRG1, CD57, CD28, CD45RA, CD45RO, CD62L, and lymphocyte subset markers (CD3, CD4, CD8, CD56) by flow cytometry |
| 17379755 | The change in T-lymphocyte KLRG1 expression was attributed to both CD4+ and CD8 bright T cells, with the relative change being greater for the CD8 bright population (P < 0 |
| 17117905 | Acute renal rejection repeatedly activates immunocompromised CD8 + T cells |
| 17117905 | Maintained activation of CD8 + T cells can induce a process of replicative senescence |
| 17117905 | In the present study, we will evaluate in CD8 lymphocytes from patients undergoing acute renal rejection characteristics of replicative senescence such as: a) low expression of CD28 molecule; b) telomere shortening and c) increase production of proinflammatory cytokines |
| 17117905 | The study was carried out in CD8 + T cells from 14 patients transplanted without clinical evidences of acute renal rejection, 14 patients kidney transplanted with clinical and anatomopathological evidences of acute renal rejection, 8 healthy controls |
| 17117905 | In conclusion our study suggest that the CD8 + T cells of patients with acute renal rejection suffer a process of replicative senescence |
| 16951325 | Mechanisms regulating the proliferative potential of human CD8+ T lymphocytes overexpressing telomerase |
| 16951325 | Using CD8+ T lymphocyte clones overexpressing telomerase, we investigated the molecular mechanisms that regulate T cell proliferation |
| 16365422 | These data suggested that homeostatic cell division in the CD8 compartment enhances the formation of TCE |
| 15882354 | These two CD8(+) T subsets exhibited an overall similar gene expression profile with only a few dozen genes that were differentially expressed |
| 15130673 | Autolysosomes accumulate during in vitro CD8+ T-lymphocyte aging and may participate in induced death sensitization of senescent cells |
| 12869504 | Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets |
| 12869504 | Our results show that sharp differences exist between the CD8 and CD4 T-cell subsets in (1) cell-cycle programs (as assessed by both in vitro proliferation and in vivo turnover measurement); (2) CD28 regulation on cell-cycle entry; and (3) accumulation of immediate effector cells among the CD28- cells, believed to be close to or at replicative senescence |
| 12869504 | We suggest that some of the T-cell aging phenomenology in RMs can be ascribed to accentuation over time of the inherent differences in activation programs in CD8 and CD4 T cells |
| 12836417 | Rapid progress has been made towards the goal of using tumor-specific cytolytic CD8+ T lymphocytes for the immunotherapy of cancer |
| 12836417 | In two of these studies, hTERT significantly extended the replicative life span of CD8+ T clones, whereas this was not the case in the third study using bulk T lymphocytes |
| 11985666 | An age-related increase in the CD28- subset was observed in CD8+ T lymphocytes in monkeys less than 11 years old and in CD4+ T lymphocytes in monkeys over 23 years old, respectively |
| 11985666 | 55) and CD8+ T lymphocytes (R = - 0 |
| 11468156 | To test whether introduction of hTERT can extend the life span of primary human T lymphocytes, naive CD8(+) T lymphocytes were transfected with retroviral vectors containing the hTERT gene |
| 11468156 | These results indicate that ectopic hTERT gene expression is capable of extending the replicative life span of primary human CD8(+) cytotoxic T lymphocytes |
| 11051194 | In the presenescent (between the 17th and 30th day) and senescent populations the majority of cells (above 90%) were CD8 positive |
| 10092696 | CONCLUSIONS: Our data indicate substantial activation of both CD4+ and CD8+ lung T cells in sarcoidosis |
| 9615924 | Cohorts of 97 centenarians, 40 subjects aged 70-90 (ELD group), and 40 young adults (under age 40) were phenotyped for T cell surface expression of CD28, CD4, and CD8 antigens |
| 9615924 | The significant decline in T cells expressing CD28 (p < 10(-4) for comparisons between adults and either ELD or centenarians) affects preferentially the CD8+ subset of T cells |
| 9433911 | Suppression of intracellular hydrogen peroxide generation and catalase levels in CD8+ T-lymphocytes from HIV+ individuals |
| 9433911 | CD8+ T-lymphocytes from HIV+ individuals contain short telomeres, a sign of cell senescence |
| 9433911 | These results suggest that CD8+ T-lymphocytes are functionally defective with the constitutively generated and PMA-elicited levels of H2O2 and the corresponding scavenger |
| 8513512 | In order to investigate whether the lack of long-lived CD8+ cells reflects phenotypic restriction, separated CD4+ and CD8+ subpopulations were transfected with SV40 large T |
| 8513512 | All transfections resulted in extended life spans of CD4+, but not CD8+, cells |
| 15374448 | The declines in vitro responses cannot be explained by decrease in numbers of differentiated T cells or by age-associated changes in the proportion of CD4+ 'helper' to CD8+ 'cytotoxic/suppressor' T cells |
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