HCSGD entry for CRLF1
1. General information
| Official gene symbol | CRLF1 |
|---|---|
| Entrez ID | 9244 |
| Gene full name | cytokine receptor-like factor 1 |
| Other gene symbols | CISS CISS1 CLF CLF-1 NR6 zcytor5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001657 | Ureteric bud development | IEA | biological_process |
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0005125 | Cytokine activity | IDA | molecular_function |
| GO:0005127 | Ciliary neurotrophic factor receptor binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0008284 | Positive regulation of cell proliferation | IDA | biological_process |
| GO:0019955 | Cytokine binding | IPI | molecular_function |
| GO:0042517 | Positive regulation of tyrosine phosphorylation of Stat3 protein | IDA | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IDA | molecular_function |
| GO:0097058 | CRLF-CLCF1 complex | IDA | cellular_component |
| GO:2000672 | Negative regulation of motor neuron apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6779241442 | 0.0065200334 | 0.9999902473 | 0.1636646226 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2780530087 |
| GSE13712_SHEAR | Down | -0.0868289571 |
| GSE13712_STATIC | Down | -0.3911866162 |
| GSE19018 | Up | 0.2446557109 |
| GSE19899_A1 | Down | -0.3422182867 |
| GSE19899_A2 | Down | -0.8727608875 |
| PubMed_21979375_A1 | Down | -0.2963514527 |
| PubMed_21979375_A2 | Down | -0.6508161928 |
| GSE35957 | Down | -0.1890921920 |
| GSE36640 | Down | -0.1317366766 |
| GSE54402 | Down | -0.3762791845 |
| GSE9593 | Down | -3.2848368416 |
| GSE43922 | Up | 0.0653480248 |
| GSE24585 | Up | 0.1102194085 |
| GSE37065 | Up | 0.3864420417 |
| GSE28863_A1 | Down | -0.5807976789 |
| GSE28863_A2 | Down | -0.4529532972 |
| GSE28863_A3 | Down | -0.1731817425 |
| GSE28863_A4 | Down | -0.2212342646 |
| GSE48662 | Up | 0.7803610134 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019983 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023159 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030308 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
