HCSGD entry for AURKB

1. General information

Official gene symbolAURKB
Entrez ID9212
Gene full nameaurora kinase B
Other gene symbolsAIK2 AIM-1 AIM1 ARK2 AurB IPL1 PPP1R48 STK12 STK5 aurkb-sv1 aurkb-sv2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000779Condensed chromosome, centromeric regionIDAcellular_component
GO:0000780Condensed nuclear chromosome, centromeric regionIDAcellular_component
GO:0002903Negative regulation of B cell apoptotic processIDAbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0004712Protein serine/threonine/tyrosine kinase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005819SpindleIEA TAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0008608Attachment of spindle microtubules to kinetochoreTASbiological_process
GO:0010369ChromocenterIEAcellular_component
GO:0016570Histone modificationTASbiological_process
GO:0030496MidbodyIEA TAScellular_component
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0032091Negative regulation of protein bindingIDAbiological_process
GO:0032133Chromosome passenger complexIEA IPI TAScellular_component
GO:0032467Positive regulation of cytokinesisIMP TASbiological_process
GO:0034501Protein localization to kinetochoreIMPbiological_process
GO:0034644Cellular response to UVIDAbiological_process
GO:0035174Histone serine kinase activityISSmolecular_function
GO:0036089Cleavage furrow formationIDAbiological_process
GO:0043146Spindle stabilizationIMPbiological_process
GO:0043988Histone H3-S28 phosphorylationISSbiological_process
GO:0046777Protein autophosphorylationTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051256Spindle midzone assembly involved in mitosisIMP TASbiological_process
GO:0051983Regulation of chromosome segregationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99019367050.00043829640.99999024730.0387127517

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3660963135
GSE13712_SHEARDown-0.5348771153
GSE13712_STATICDown-0.4735328197
GSE19018Up0.0010010886
GSE19899_A1Down-0.7072196429
GSE19899_A2Down-2.8217035140
PubMed_21979375_A1Down-0.4795093981
PubMed_21979375_A2Down-2.8181736951
GSE35957Down-1.7991183712
GSE36640Down-2.6234149113
GSE54402Down-0.5238880695
GSE9593Down-0.9634542855
GSE43922Down-0.9951010665
GSE24585Down-0.1796287925
GSE37065Down-0.2570987613
GSE28863_A1Down-0.0711019508
GSE28863_A2Up0.0085131879
GSE28863_A3Up0.2846304345
GSE28863_A4Up0.2613508386
GSE48662Down-1.3311954164

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

HESPERIDINDB04703 -
AT9283DB05169 -
N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamineDB07340 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-24-3pMIMAT0000080MIRT000120Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay;Western blot;qRT-PCR;OtherFunctional MTI19748357
hsa-let-7b-5pMIMAT0000063MIRT001649pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-16-5pMIMAT0000069MIRT004742Microarray//qRT-PCRFunctional MTI (Weak)19738602
hsa-miR-16-5pMIMAT0000069MIRT004742ProteomicsFunctional MTI (Weak)18668040
hsa-miR-155-5pMIMAT0000646MIRT020616ProteomicsFunctional MTI (Weak)18668040
hsa-miR-124-3pMIMAT0000422MIRT022319Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-125b-5pMIMAT0000423MIRT046053CLASHFunctional MTI (Weak)23622248
hsa-miR-148a-3pMIMAT0000243MIRT048044CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049133CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-204-5pMIMAT0000265NAhsa-miR-20420369013
hsa-miR-24-3pMIMAT00000801hsa-miR-2419748357
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26133385Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition
26133385Downstream analyses show that all of the compounds that induce tetraploid senescence inhibit Aurora kinase B (AURKB)
26133385AURKB is the catalytic component of the chromosome passenger complex, which is involved in correct chromosome alignment and segregation, the spindle assembly checkpoint, and cytokinesis
26133385Although aberrant mitosis and senescence have been linked, a specific characterization of AURKB in the context of senescence is still required
26133385This proof-of-principle study suggests that our protocol is capable of amplifying tetraploid senescence, which can be observed in only a small population of oncogenic RAS-induced senescence, and provides additional justification for AURKB as a cancer therapeutic target
22024481Aurora B kinase (Aurora-B) functions in chromosome segregation and cleavage of polar spindle microtubules
22024481Here, we investigated Aurora-B effects on cellular senescence in human fibroblasts and endothelial cells
22024481Aurora-B levels were reduced during replicative senescence and premature senescence by adriamycin
22024481Aurora-B overexpression in old cells partially reversed senescence phenotypes
22024481In contrast, Aurora-B down-regulation accelerated cellular senescence
22024481These results suggest that Aurora-B might function in the regulation of cellular senescence of human primary cells via a p53-dependent pathway
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