HCSGD entry for LRRFIP1
1. General information
| Official gene symbol | LRRFIP1 |
|---|---|
| Entrez ID | 9208 |
| Gene full name | leucine rich repeat (in FLII) interacting protein 1 |
| Other gene symbols | FLAP-1 FLAP1 FLIIAP1 GCF-2 GCF2 HUFI-1 TRIP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003725 | Double-stranded RNA binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005634 | Nucleus | NAS | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0032481 | Positive regulation of type I interferon production | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8970255879 | 0.1219044375 | 0.9999902473 | 0.6700586358 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2259396206 |
| GSE13712_SHEAR | Up | 0.5988449433 |
| GSE13712_STATIC | Up | 0.3631784864 |
| GSE19018 | Down | -0.0850244084 |
| GSE19899_A1 | Down | -0.2814733490 |
| GSE19899_A2 | Up | 0.0165345748 |
| PubMed_21979375_A1 | Down | -0.3616612396 |
| PubMed_21979375_A2 | Down | -0.3227513926 |
| GSE35957 | Up | 0.0627984341 |
| GSE36640 | Down | -0.2550164771 |
| GSE54402 | Down | -0.1296814518 |
| GSE9593 | Up | 0.0647480633 |
| GSE43922 | Down | -0.1211362052 |
| GSE24585 | Down | -0.2801856977 |
| GSE37065 | Up | 0.1966554011 |
| GSE28863_A1 | Down | -0.1702686966 |
| GSE28863_A2 | Up | 0.3429608281 |
| GSE28863_A3 | Down | -0.2746203512 |
| GSE28863_A4 | Down | -0.0845482452 |
| GSE48662 | Down | -0.3440317949 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT001220 | semi-qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19559015 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005182 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024762 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025366 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026309 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037048 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037289 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045105 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045426 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | 1 | hsa-miR-21 | {Western blot} | {downregulation} | 19559015 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
