HCSGD entry for SLC16A7
1. General information
| Official gene symbol | SLC16A7 |
|---|---|
| Entrez ID | 9194 |
| Gene full name | solute carrier family 16, member 7 (monocarboxylic acid transporter 2) |
| Other gene symbols | MCT2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005477 | Pyruvate secondary active transmembrane transporter activity | TAS | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0015129 | Lactate transmembrane transporter activity | IDA | molecular_function |
| GO:0015293 | Symporter activity | IEA | molecular_function |
| GO:0015355 | Secondary active monocarboxylate transmembrane transporter activity | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0035873 | Lactate transmembrane transport | IMP | biological_process |
| GO:0050833 | Pyruvate transmembrane transporter activity | IDA | molecular_function |
| GO:0055085 | Transmembrane transport | IEA TAS | biological_process |
| GO:1901475 | Pyruvate transmembrane transport | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8094102428 | 0.0010382432 | 0.9999902473 | 0.0614662921 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4434724279 |
| GSE13712_SHEAR | Down | -0.6334237690 |
| GSE13712_STATIC | Down | -0.1885566472 |
| GSE19018 | Down | -0.6332567651 |
| GSE19899_A1 | Down | -0.4877071147 |
| GSE19899_A2 | Down | -1.0657770407 |
| PubMed_21979375_A1 | Down | -0.8678479196 |
| PubMed_21979375_A2 | Down | -1.0932662540 |
| GSE35957 | Up | 0.3904036067 |
| GSE36640 | Down | -0.6844412322 |
| GSE54402 | Down | -0.5636658763 |
| GSE9593 | Down | -0.7329696543 |
| GSE43922 | Down | -1.1355693642 |
| GSE24585 | Up | 1.9673045205 |
| GSE37065 | Down | -0.2695323685 |
| GSE28863_A1 | Up | 0.5467162267 |
| GSE28863_A2 | Up | 0.1501537329 |
| GSE28863_A3 | Down | -1.4269158345 |
| GSE28863_A4 | Down | -0.0183408305 |
| GSE48662 | Down | -0.4262275169 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024296 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026289 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22964484 | Inhibition of monocarboxylate transporter 2 induces senescence-associated mitochondrial dysfunction and suppresses progression of colorectal malignancies in vivo |
| 22964484 | In the present study, we show that the monocarboxylate transporter 2 (MCT2) protein was tumor-selectively expressed in human colorectal malignancies and knockdown of MCT2 induces mitochondrial dysfunction, cell-cycle arrest, and senescence without additional cellular stress in colorectal cancer cell lines |
| 22964484 | Moreover, the reactive oxygen species (ROS) scavenger, N-acetylcysteine, blocked MCT2 knockdown-induced growth arrest and cellular senescence, indicating a pivotal role of ROS in this pathway |
| 22964484 | Dramatic induction of mitochondrial superoxide generation and decrease in ATP production was observed, indicating that mitochondrial dysfunction is the major mechanism underlying MCT2 knockdown-induced ROS generation |
| 22964484 | Conversely, overexpression of MCT2 prevented doxorubicin-induced ROS accumulation (P = 0 |
| 22964484 | MCT2 knockdown suppressed KRAS mutant colorectal tumor growth in vivo |
| 22964484 | In addition, MCT2 knockdown and cytostatic drug combination further enhanced the antitumor effect |
| 22964484 | These findings support the use of MCT2 as a promising target for inhibition of colorectal cancer |
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