HCSGD entry for NEK9
1. General information
| Official gene symbol | NEK9 |
|---|---|
| Entrez ID | 91754 |
| Gene full name | NIMA-related kinase 9 |
| Other gene symbols | NERCC NERCC1 Nek8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | EXP IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007077 | Mitotic nuclear envelope disassembly | TAS | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9003277725 | 0.1026529615 | 0.9999902473 | 0.6138107451 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0670092456 |
| GSE13712_SHEAR | Down | -0.1831676970 |
| GSE13712_STATIC | Down | -0.0356237077 |
| GSE19018 | Down | -0.0862932356 |
| GSE19899_A1 | Down | -0.3396157697 |
| GSE19899_A2 | Down | -0.2359950316 |
| PubMed_21979375_A1 | Down | -0.6773139580 |
| PubMed_21979375_A2 | Down | -0.2581343007 |
| GSE35957 | Up | 0.0071868366 |
| GSE36640 | Down | -0.0054069634 |
| GSE54402 | Down | -0.1769731604 |
| GSE9593 | Up | 0.0376104717 |
| GSE43922 | Down | -0.8502234198 |
| GSE24585 | Up | 0.3157917065 |
| GSE37065 | Down | -0.1147557933 |
| GSE28863_A1 | Up | 0.1586968591 |
| GSE28863_A2 | Down | -0.0442518757 |
| GSE28863_A3 | Down | -0.1760433726 |
| GSE28863_A4 | Up | 0.0976176224 |
| GSE48662 | Up | 0.3702656507 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002635 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002635 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029337 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040420 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042950 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052110 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
