HCSGD entry for MAP3K13
1. General information
| Official gene symbol | MAP3K13 |
|---|---|
| Entrez ID | 9175 |
| Gene full name | mitogen-activated protein kinase kinase kinase 13 |
| Other gene symbols | LZK MEKK13 MLK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | IDA | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007254 | JNK cascade | IDA | biological_process |
| GO:0008385 | IkappaB kinase complex | IDA | cellular_component |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0019901 | Protein kinase binding | ISS | molecular_function |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4117256449 | 0.8855361764 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0147395074 |
| GSE13712_SHEAR | Up | 0.0682977514 |
| GSE13712_STATIC | Up | 0.0165870990 |
| GSE19018 | Up | 0.0077901568 |
| GSE19899_A1 | Down | -0.0748969200 |
| GSE19899_A2 | Up | 0.1095472720 |
| PubMed_21979375_A1 | Up | 0.3668865731 |
| PubMed_21979375_A2 | Down | -0.0856149576 |
| GSE35957 | Down | -0.0048944647 |
| GSE36640 | Down | -0.0020568831 |
| GSE54402 | Up | 0.3018218691 |
| GSE9593 | Down | -0.0925319900 |
| GSE43922 | Up | 0.4219679611 |
| GSE24585 | Up | 0.3364873823 |
| GSE37065 | Up | 0.2557029234 |
| GSE28863_A1 | Up | 0.0130608164 |
| GSE28863_A2 | Up | 0.2197892862 |
| GSE28863_A3 | Down | -0.1954488441 |
| GSE28863_A4 | Down | -0.1652435906 |
| GSE48662 | Down | -0.0971756481 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-93-5p | MIMAT0000093 | MIRT048810 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
