HCSGD entry for CCNE2
1. General information
| Official gene symbol | CCNE2 |
|---|---|
| Entrez ID | 9134 |
| Gene full name | cyclin E2 |
| Other gene symbols | CYCE2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000075 | Cell cycle checkpoint | TAS | biological_process |
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | IEA | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006270 | DNA replication initiation | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0016538 | Cyclin-dependent protein serine/threonine kinase regulator activity | IEA | molecular_function |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0051301 | Cell division | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9047073287 | 0.0000631549 | 0.9999902473 | 0.0130889764 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4067227901 |
| GSE13712_SHEAR | Up | 0.4937032698 |
| GSE13712_STATIC | Down | -0.3435936603 |
| GSE19018 | Down | -1.2762027185 |
| GSE19899_A1 | Down | -0.5786953441 |
| GSE19899_A2 | Down | -3.2075881958 |
| PubMed_21979375_A1 | Down | -2.1782424006 |
| PubMed_21979375_A2 | Down | -4.7794189331 |
| GSE35957 | Down | -2.8705127242 |
| GSE36640 | Down | -3.4403625438 |
| GSE54402 | Down | -0.4502481505 |
| GSE9593 | Down | -1.5979603383 |
| GSE43922 | Down | -2.2120812750 |
| GSE24585 | Up | 0.7015078948 |
| GSE37065 | Down | -0.4455052653 |
| GSE28863_A1 | Down | -0.5248878382 |
| GSE28863_A2 | Up | 0.8308004277 |
| GSE28863_A3 | Down | -0.1631640943 |
| GSE28863_A4 | Up | 0.1976096057 |
| GSE48662 | Down | -0.8971558681 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26a-5p | MIMAT0000082 | MIRT000111 | Luciferase reporter assay//Western blot | Functional MTI | 19524505 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT000645 | Luciferase reporter assay | Functional MTI | 19956200 |
| hsa-miR-449a | MIMAT0001541 | MIRT006347 | Luciferase reporter assay//Western blot | Functional MTI | 21418558 |
| hsa-miR-34c-5p | MIMAT0000686 | MIRT000766 | Luciferase reporter assay | Functional MTI | 19461653 |
| hsa-miR-34b-5p | MIMAT0000685 | MIRT000767 | Luciferase reporter assay | Functional MTI | 19461653 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT000768 | Luciferase reporter assay | Functional MTI | 19461653 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT000768 | Luciferase reporter assay//Western blot//Microarray | Functional MTI | 17914404 |
| hsa-miR-126-3p | MIMAT0000445 | MIRT000965 | Luciferase reporter assay | Non-Functional MTI | 18834857 |
| hsa-miR-449b-5p | MIMAT0003327 | MIRT006350 | Luciferase reporter assay//Western blot | Functional MTI | 21418558 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT006303 | Luciferase reporter assay//qRT-PCR | Functional MTI | 22384020 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT006665 | Luciferase reporter assay | Functional MTI | 22183793 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT006666 | Luciferase reporter assay | Functional MTI | 22183793 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT006667 | Luciferase reporter assay | Functional MTI | 22183793 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028325 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031722 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048230 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050210 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27362652 | Targets of miR-34 miRNAs, including E2F1, c-Myc, and cyclin E2, were lower in IPF type II AECs |
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