HCSGD entry for AIFM1
1. General information
| Official gene symbol | AIFM1 |
|---|---|
| Entrez ID | 9131 |
| Gene full name | apoptosis-inducing factor, mitochondrion-associated, 1 |
| Other gene symbols | AIF CMTX4 COWCK COXPD6 PDCD8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA ISS | cellular_component |
| GO:0005739 | Mitochondrion | IEA TAS | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0005758 | Mitochondrial intermembrane space | IDA IMP | cellular_component |
| GO:0005829 | Cytosol | ISS | cellular_component |
| GO:0006308 | DNA catabolic process | TAS | biological_process |
| GO:0006309 | Apoptotic DNA fragmentation | IEA | biological_process |
| GO:0006915 | Apoptotic process | IMP | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0016174 | NAD(P)H oxidase activity | TAS | molecular_function |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0016651 | Oxidoreductase activity, acting on NAD(P)H | IDA | molecular_function |
| GO:0030182 | Neuron differentiation | IDA | biological_process |
| GO:0030261 | Chromosome condensation | TAS | biological_process |
| GO:0032981 | Mitochondrial respiratory chain complex I assembly | IMP | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0045454 | Cell redox homeostasis | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0050660 | Flavin adenine dinucleotide binding | IEA | molecular_function |
| GO:0051402 | Neuron apoptotic process | IEA | biological_process |
| GO:0070059 | Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0175228525 | 0.9694990882 | 0.3251440141 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6321792863 |
| GSE13712_SHEAR | Down | -0.2966234316 |
| GSE13712_STATIC | Up | 0.0487372519 |
| GSE19018 | Up | 0.0810379550 |
| GSE19899_A1 | Up | 0.6351193705 |
| GSE19899_A2 | Up | 0.4148280759 |
| PubMed_21979375_A1 | Up | 0.2410334194 |
| PubMed_21979375_A2 | Up | 1.0323199072 |
| GSE35957 | Down | -0.5540858347 |
| GSE36640 | Up | 0.2325143424 |
| GSE54402 | Up | 0.2382398453 |
| GSE9593 | Down | -0.2417262766 |
| GSE43922 | Up | 0.3387291891 |
| GSE24585 | Down | -0.0406266560 |
| GSE37065 | Up | 0.1343124271 |
| GSE28863_A1 | Up | 0.2485103895 |
| GSE28863_A2 | Up | 0.4270709705 |
| GSE28863_A3 | Up | 0.2147293624 |
| GSE28863_A4 | Up | 0.2543502290 |
| GSE48662 | Up | 0.0106674616 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| MCC | DB05282 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020612 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028978 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036812 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042266 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047896 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11304688 | Medium conditioned by such terminally differentiating cells contains a small cytokine-like factor (AAV-induced factor [AIF]) |
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