HCSGD entry for RGN
1. General information
| Official gene symbol | RGN |
|---|---|
| Entrez ID | 9104 |
| Gene full name | regucalcin (senescence marker protein-30) |
| Other gene symbols | GNL RC SMP30 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004341 | Gluconolactonase activity | IDA | molecular_function |
| GO:0005509 | Calcium ion binding | IDA ISS | molecular_function |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0006874 | Cellular calcium ion homeostasis | ISS | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0019853 | L-ascorbic acid biosynthetic process | IEA | biological_process |
| GO:0030234 | Enzyme regulator activity | IEA | molecular_function |
| GO:0032781 | Positive regulation of ATPase activity | ISS | biological_process |
| GO:0050848 | Regulation of calcium-mediated signaling | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9489469131 | 0.0216283348 | 0.9999902473 | 0.2837565455 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3909124778 |
| GSE13712_SHEAR | Up | 0.1322195738 |
| GSE13712_STATIC | Up | 0.0154384696 |
| GSE19018 | Down | -0.2483792688 |
| GSE19899_A1 | Up | 0.1334849288 |
| GSE19899_A2 | Down | -0.0727726621 |
| PubMed_21979375_A1 | Down | -0.8330124732 |
| PubMed_21979375_A2 | Down | -0.3960268582 |
| GSE35957 | Up | 0.2942951231 |
| GSE36640 | Down | -1.3179999149 |
| GSE54402 | Down | -0.8219036086 |
| GSE9593 | Down | -0.4802988945 |
| GSE43922 | Up | 0.0153269426 |
| GSE24585 | Up | 0.0816699148 |
| GSE37065 | Down | -0.0059947047 |
| GSE28863_A1 | Down | -0.1220700180 |
| GSE28863_A2 | Down | -0.0439537155 |
| GSE28863_A3 | Down | -0.4525500296 |
| GSE28863_A4 | Down | -0.0622926779 |
| GSE48662 | Down | -0.1480408257 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023777 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23933320 | BACKGROUND AND OBJECTIVE: Senescence marker protein 30 (SMP30) is assumed to behave as an anti-aging factor |
| 23933320 | Recently, we have demonstrated that deficiency of SMP30 exacerbates angiotensin II-induced cardiac hypertrophy, dysfunction and remodeling, suggesting that SMP30 may have a protective role in the heart |
| 23933320 | Thus, this study aimed to test the hypothesis that up-regulation of SMP30 inhibits cardiac adverse remodeling in response to angiotensin II |
| 23933320 | METHODS: We generated transgenic mice with cardiac-specific overexpression of SMP30 gene using alpha-myosin heavy chain promoter |
| 23933320 | CONCLUSIONS: Cardiac-specific overexpression of SMP30 inhibited angiotensin II-induced cardiac adverse remodeling |
| 23933320 | SMP30 has a cardio-protective role with anti-oxidative and anti-aging effects and could be a novel therapeutic target to prevent cardiac hypertrophy and remodeling due to hypertension |
| 22207551 | In the present study, we have examined age-related histological changes in the livers of senescence marker protein knockout (SMP30-/-) mice, which are considered as a murine aging model due to the more sensitive response to apoptotic reagents and due to their shorter life span |
| 22207551 | In livers of old SMP30-/- mice, numerous hepatic stellate cells (HSCs) were hypertrophic and contained abundant microvesicular lipid droplets in cytoplasm |
| 16874657 | Accelerated tubular cell senescence in SMP30 knockout mice |
| 16874657 | Therefore, we established a SMP30 deficient strain of mice with a C57BL/6 background by gene targeting to investigate whether this molecule is involved in renal tubular cell senescence |
| 16874657 | Male SMP30 knockout (SMP30Y/-) mice and male wild-type (SMPY/+) mice (n=5) aged 12 months were examined histologically |
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