HCSGD entry for IL33

1. General information

Official gene symbolIL33
Entrez ID90865
Gene full nameinterleukin 33
Other gene symbolsC9orf26 DVS27 IL1F11 NF-HEV NFEHEV RP11-575C20.2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002686Negative regulation of leukocyte migrationIEAbiological_process
GO:0002826Negative regulation of T-helper 1 type immune responseIEAbiological_process
GO:0002830Positive regulation of type 2 immune responseIEAbiological_process
GO:0005125Cytokine activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005694ChromosomeIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0030133Transport vesicleIEAcellular_component
GO:0032689Negative regulation of interferon-gamma productionIEAbiological_process
GO:0032736Positive regulation of interleukin-13 productionIEAbiological_process
GO:0032753Positive regulation of interleukin-4 productionIEAbiological_process
GO:0032754Positive regulation of interleukin-5 productionIEAbiological_process
GO:0032755Positive regulation of interleukin-6 productionIEAbiological_process
GO:0043032Positive regulation of macrophage activationIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0050729Positive regulation of inflammatory responseISSbiological_process
GO:0051024Positive regulation of immunoglobulin secretionIEAbiological_process
GO:0051025Negative regulation of immunoglobulin secretionIEAbiological_process
GO:0090197Positive regulation of chemokine secretionIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00009523950.12997531630.02777526880.6940718807

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up3.0222500470
GSE13712_SHEARDown-2.5491607790
GSE13712_STATICDown-1.8311996821
GSE19018Down-2.2081622428
GSE19899_A1Up1.4054580428
GSE19899_A2Up2.3762042425
PubMed_21979375_A1Up4.7207846079
PubMed_21979375_A2Up1.7174602011
GSE35957Down-0.2582680892
GSE36640Up0.0172127902
GSE54402Up2.0206950083
GSE9593Down-0.0670314598
GSE43922Up0.4671686148
GSE24585Up0.7198290599
GSE37065Up1.9429842414
GSE28863_A1Up1.6218169508
GSE28863_A2Down-0.2599897908
GSE28863_A3Up0.7181273529
GSE28863_A4Up0.2946489044
GSE48662Down-0.2888204295

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017750MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.