HCSGD entry for MAP3K6
1. General information
| Official gene symbol | MAP3K6 |
|---|---|
| Entrez ID | 9064 |
| Gene full name | mitogen-activated protein kinase kinase kinase 6 |
| Other gene symbols | ASK2 MAPKKK6 MEKK6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | IDA | biological_process |
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007257 | Activation of JUN kinase activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2858989324 | 0.6479934691 | 0.9853536467 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0005517610 |
| GSE13712_SHEAR | Up | 0.1348824800 |
| GSE13712_STATIC | Down | -0.1040388323 |
| GSE19018 | Up | 0.0522775457 |
| GSE19899_A1 | Down | -0.0865897888 |
| GSE19899_A2 | Down | -0.2564963601 |
| PubMed_21979375_A1 | Up | 0.0066479335 |
| PubMed_21979375_A2 | Up | 0.0376842348 |
| GSE35957 | Down | -0.2646531396 |
| GSE36640 | Down | -0.0198409237 |
| GSE54402 | Down | -0.0513569605 |
| GSE9593 | Up | 0.0672649353 |
| GSE43922 | Up | 0.0090512298 |
| GSE24585 | Up | 1.0162462735 |
| GSE37065 | Down | -0.2299135302 |
| GSE28863_A1 | Up | 0.3477543294 |
| GSE28863_A2 | Up | 0.5993777794 |
| GSE28863_A3 | Down | -0.1036995974 |
| GSE28863_A4 | Down | -0.1615186733 |
| GSE48662 | Up | 0.2863989149 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049479 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
