HCSGD entry for PIAS2
1. General information
| Official gene symbol | PIAS2 |
|---|---|
| Entrez ID | 9063 |
| Gene full name | protein inhibitor of activated STAT, 2 |
| Other gene symbols | ARIP3 DIP MIZ MIZ1 PIASX PIASX-ALPHA PIASX-BETA SIZ2 ZMIZ4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016604 | Nuclear body | IEA | cellular_component |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0016925 | Protein sumoylation | IDA IEA | biological_process |
| GO:0019789 | SUMO ligase activity | IDA IEA | molecular_function |
| GO:0030521 | Androgen receptor signaling pathway | NAS | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IEA | molecular_function |
| GO:0045667 | Regulation of osteoblast differentiation | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0050681 | Androgen receptor binding | NAS | molecular_function |
| GO:0060766 | Negative regulation of androgen receptor signaling pathway | IDA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9406331636 | 0.3531157441 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2881389429 |
| GSE13712_SHEAR | Down | -0.1675366657 |
| GSE13712_STATIC | Down | -0.1925567146 |
| GSE19018 | Up | 0.0034636416 |
| GSE19899_A1 | Up | 0.0546791531 |
| GSE19899_A2 | Up | 0.0727586702 |
| PubMed_21979375_A1 | Down | -0.1284094291 |
| PubMed_21979375_A2 | Up | 0.3425883905 |
| GSE35957 | Down | -0.0402276859 |
| GSE36640 | Down | -0.3590477590 |
| GSE54402 | Up | 0.1136535067 |
| GSE9593 | Up | 0.0064237141 |
| GSE43922 | Up | 0.0182732275 |
| GSE24585 | Up | 0.0893048217 |
| GSE37065 | Down | -0.1128728276 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.2607646925 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029164 | Microarray | Functional MTI (Weak) | 19088304 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20818171 | Additional cellular activities have been identified that suppress Myc-induced senescence, including the Wrn helicase, Telomerase and Miz1 |
| 20818171 | These senescencesuppressing activities were critical for tumor progression, as deficiency in either Cdk2, telomerase or Miz1 reduced the onset of Myc-induced lymphoma in transgenic mice |
Entries Per Page
Displaying Page of
