HCSGD entry for MCU
1. General information
| Official gene symbol | MCU |
|---|---|
| Entrez ID | 90550 |
| Gene full name | mitochondrial calcium uniporter |
| Other gene symbols | C10orf42 CCDC109A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005262 | Calcium channel activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IDA | cellular_component |
| GO:0006851 | Mitochondrial calcium ion transport | IDA IMP | biological_process |
| GO:0015292 | Uniporter activity | IDA | molecular_function |
| GO:0019722 | Calcium-mediated signaling | IDA | biological_process |
| GO:0031305 | Integral component of mitochondrial inner membrane | IDA | cellular_component |
| GO:0032024 | Positive regulation of insulin secretion | IMP | biological_process |
| GO:0034704 | Calcium channel complex | ISS | cellular_component |
| GO:0035786 | Protein complex oligomerization | IDA | biological_process |
| GO:0042593 | Glucose homeostasis | IMP | biological_process |
| GO:0051561 | Positive regulation of mitochondrial calcium ion concentration | IDA IMP | biological_process |
| GO:1990246 | Uniplex complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5725018578 | 0.0649954713 | 0.9999902473 | 0.4813578503 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9585866895 |
| GSE13712_SHEAR | Up | 0.1372717129 |
| GSE13712_STATIC | Up | 0.0498447010 |
| GSE19018 | Up | 0.0892290993 |
| GSE19899_A1 | Down | -0.3868964371 |
| GSE19899_A2 | Up | 0.1478972155 |
| PubMed_21979375_A1 | Down | -0.6105425547 |
| PubMed_21979375_A2 | Up | 0.6325159382 |
| GSE35957 | Down | -0.0090137360 |
| GSE36640 | Down | -0.0762358565 |
| GSE54402 | Down | -0.2093945972 |
| GSE9593 | Up | 0.1804501183 |
| GSE43922 | Down | -0.0502985525 |
| GSE24585 | Up | 0.1930748228 |
| GSE37065 | Up | 0.0047402139 |
| GSE28863_A1 | Down | -0.0747798115 |
| GSE28863_A2 | Down | -0.3634467962 |
| GSE28863_A3 | Down | -0.2738482926 |
| GSE28863_A4 | Up | 0.1154197571 |
| GSE48662 | Down | -0.2901951698 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT005270 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047735 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050443 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
