HCSGD entry for UBE2M
1. General information
| Official gene symbol | UBE2M |
|---|---|
| Entrez ID | 9040 |
| Gene full name | ubiquitin-conjugating enzyme E2M |
| Other gene symbols | UBC-RS2 UBC12 hUbc12 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IMP TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0006464 | Cellular protein modification process | IMP TAS | biological_process |
| GO:0016567 | Protein ubiquitination | IMP TAS | biological_process |
| GO:0016881 | Acid-amino acid ligase activity | IEA | molecular_function |
| GO:0018169 | Ribosomal S6-glutamic acid ligase activity | IDA | molecular_function |
| GO:0019788 | NEDD8 ligase activity | IDA | molecular_function |
| GO:0043525 | Positive regulation of neuron apoptotic process | IEA | biological_process |
| GO:0045116 | Protein neddylation | IDA IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0387352228 | 0.8030934881 | 0.4442262402 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6381554621 |
| GSE13712_SHEAR | Up | 0.1999624459 |
| GSE13712_STATIC | Up | 0.0660471025 |
| GSE19018 | Down | -0.0572455289 |
| GSE19899_A1 | Up | 0.2587621090 |
| GSE19899_A2 | Up | 0.9059008726 |
| PubMed_21979375_A1 | Up | 1.6387601523 |
| PubMed_21979375_A2 | Up | 0.3218086293 |
| GSE35957 | Down | -0.5981130535 |
| GSE36640 | Down | -0.1672257796 |
| GSE54402 | Up | 0.8057126630 |
| GSE9593 | Up | 0.1585938416 |
| GSE43922 | Up | 0.0105429546 |
| GSE24585 | Down | -0.4128829041 |
| GSE37065 | Down | -0.1513624163 |
| GSE28863_A1 | Up | 0.0221339281 |
| GSE28863_A2 | Down | -0.0615054098 |
| GSE28863_A3 | Up | 0.1798650574 |
| GSE28863_A4 | Up | 0.0903692779 |
| GSE48662 | Up | 0.0293043759 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT032277 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048746 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
