HCSGD entry for TICRR
1. General information
| Official gene symbol | TICRR |
|---|---|
| Entrez ID | 90381 |
| Gene full name | TOPBP1-interacting checkpoint and replication regulator |
| Other gene symbols | C15orf42 SLD3 Treslin |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000075 | Cell cycle checkpoint | ISS | biological_process |
| GO:0001731 | Formation of translation preinitiation complex | ISS | biological_process |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0006260 | DNA replication | IEA ISS | biological_process |
| GO:0006281 | DNA repair | ISS | biological_process |
| GO:0010212 | Response to ionizing radiation | IEA ISS | biological_process |
| GO:0030174 | Regulation of DNA-dependent DNA replication initiation | IMP | biological_process |
| GO:0033314 | Mitotic DNA replication checkpoint | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7565409635 | 0.0427522852 | 0.9999902473 | 0.3888330684 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1647170665 |
| GSE13712_SHEAR | Down | -0.0509624771 |
| GSE13712_STATIC | Up | 0.1016498852 |
| GSE19018 | Up | 0.0271527618 |
| GSE19899_A1 | Up | 0.1136999342 |
| GSE19899_A2 | Down | -0.6681080221 |
| PubMed_21979375_A1 | Up | 0.1917050404 |
| PubMed_21979375_A2 | Down | -0.2988818091 |
| GSE35957 | Down | -0.0920175736 |
| GSE36640 | Down | -1.2463547037 |
| GSE54402 | Down | -0.1486812774 |
| GSE9593 | Down | -0.2940482195 |
| GSE43922 | Down | -0.4439019371 |
| GSE24585 | Down | -0.2860719198 |
| GSE37065 | Down | -0.4769178301 |
| GSE28863_A1 | Down | -0.0470047937 |
| GSE28863_A2 | Up | 0.9938793573 |
| GSE28863_A3 | Up | 0.1559809923 |
| GSE28863_A4 | Up | 0.1473283860 |
| GSE48662 | Down | -0.5802882145 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016497 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024867 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026533 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
