HCSGD entry for MAP3K14
1. General information
| Official gene symbol | MAP3K14 |
|---|---|
| Entrez ID | 9020 |
| Gene full name | mitogen-activated protein kinase kinase kinase 14 |
| Other gene symbols | FTDCR1B HS HSNIK NIK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0004704 | NF-kappaB-inducing kinase activity | ISS | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006955 | Immune response | ISS | biological_process |
| GO:0007249 | I-kappaB kinase/NF-kappaB signaling | ISS | biological_process |
| GO:0023014 | Signal transduction by phosphorylation | ISS | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0038061 | NIK/NF-kappaB signaling | ISS | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IMP RCA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0071260 | Cellular response to mechanical stimulus | IEP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9615397097 | 0.0328782265 | 0.9999902473 | 0.3423211234 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1756637625 |
| GSE13712_SHEAR | Down | -0.0075010828 |
| GSE13712_STATIC | Down | -0.3155782074 |
| GSE19018 | Down | -0.1702485012 |
| GSE19899_A1 | Down | -0.0934460174 |
| GSE19899_A2 | Down | -0.7255691281 |
| PubMed_21979375_A1 | Down | -0.7512267041 |
| PubMed_21979375_A2 | Down | -0.5455881925 |
| GSE35957 | Down | -0.4039589504 |
| GSE36640 | Down | -0.4487378516 |
| GSE54402 | Down | -0.4278515930 |
| GSE9593 | Up | 0.1106177432 |
| GSE43922 | Down | -0.4032152103 |
| GSE24585 | Up | 0.0131391797 |
| GSE37065 | Down | -0.4306962924 |
| GSE28863_A1 | Up | 0.0519076232 |
| GSE28863_A2 | Up | 0.0540358566 |
| GSE28863_A3 | Up | 0.1469980684 |
| GSE28863_A4 | Up | 0.1532176274 |
| GSE48662 | Up | 0.0228841461 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020850 | Reporter assay | Functional MTI | 20584899 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
