HCSGD entry for KALRN

1. General information

Official gene symbolKALRN
Entrez ID8997
Gene full namekalirin, RhoGEF kinase
Other gene symbolsARHGEF24 CHD5 CHDS5 DUET DUO HAPIP TRAD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007399Nervous system developmentISSbiological_process
GO:0015629Actin cytoskeletonTAScellular_component
GO:0016192Vesicle-mediated transportTASbiological_process
GO:0035556Intracellular signal transductionISSbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043087Regulation of GTPase activityTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.90436561680.15633027240.99999024730.7633418290

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0326730557
GSE13712_SHEARDown-0.4520246332
GSE13712_STATICDown-0.2937254920
GSE19018Down-0.0608883471
GSE19899_A1Up0.0497851460
GSE19899_A2Down-0.4303263605
PubMed_21979375_A1Down-0.3179248379
PubMed_21979375_A2Down-0.0310041805
GSE35957Down-0.0370938631
GSE36640Up0.0429128154
GSE54402Down-0.0335735881
GSE9593Down-0.2786455057
GSE43922Down-0.1451816040
GSE24585Down-0.1813179849
GSE37065Down-0.0981919077
GSE28863_A1Down-0.2484338988
GSE28863_A2Up0.5366587369
GSE28863_A3Up0.4103967130
GSE28863_A4Down-0.0037095616
GSE48662Up0.0401989020

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018300MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.