HCSGD entry for SELENBP1
1. General information
| Official gene symbol | SELENBP1 |
|---|---|
| Entrez ID | 8991 |
| Gene full name | selenium binding protein 1 |
| Other gene symbols | LPSB SBP56 SP56 hSBP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0008430 | Selenium binding | IEA | molecular_function |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9044548687 | 0.0004773451 | 0.9999902473 | 0.0410707792 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1111993867 |
| GSE13712_SHEAR | Down | -1.8179458802 |
| GSE13712_STATIC | Down | -1.0562638719 |
| GSE19018 | Down | -0.8980536591 |
| GSE19899_A1 | Down | -1.0456586964 |
| GSE19899_A2 | Down | -2.2261128544 |
| PubMed_21979375_A1 | Down | -1.2723886217 |
| PubMed_21979375_A2 | Down | -1.5427438579 |
| GSE35957 | Down | -1.6340059017 |
| GSE36640 | Up | 0.0328406042 |
| GSE54402 | Down | -0.5977325840 |
| GSE9593 | Down | -0.2375561918 |
| GSE43922 | Down | -1.2170851258 |
| GSE24585 | Up | 1.0046789585 |
| GSE37065 | Up | 0.0341878098 |
| GSE28863_A1 | Up | 0.5796060070 |
| GSE28863_A2 | Down | -0.5842865552 |
| GSE28863_A3 | Down | -0.3050953621 |
| GSE28863_A4 | Up | 0.1620243745 |
| GSE48662 | Down | -0.1802372087 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017378 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029152 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049678 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050594 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20332323 | Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity |
| 20332323 | EXPERIMENTAL DESIGN: SELENBP1 expression level and copy number variation were determined by oligonucleotide microarrays, real-time reverse transcription-PCR, tissue microarrays, immunoblotting, and single-nucleotide polymorphism arrays |
| 20332323 | Bisulfite sequencing and sequence analysis of reverse transcription-PCR-amplified products explored epigenetic and posttranscriptional regulation of SELENBP1 expression, respectively |
| 20332323 | WST-1 cell proliferation assays, senescence-associated beta-galactosidase staining, immunoblotting, and flow cytometry were done to evaluate the biological significance of SELENBP1 overexpression in selenium-supplemented EAC cells |
| 20332323 | RESULTS: SELENBP1 expression decreased significantly in Barrett's esophagus to adenocarcinoma progression |
| 20332323 | Both epigenetic and posttranscriptional mechanisms seemed to modulate SELENBP1 expression |
| 20332323 | Stable overexpression of SELENBP1 in methylseleninic acid-supplemented Flo-1 cells resulted in enhanced apoptosis, increased cellular senescence, and enhanced cisplatin cytotoxicity |
| 20332323 | CONCLUSIONS: SELENBP1 expression may be an important predictor of response to chemoprevention or chemosensitization with certain forms of selenium in esophageal tissues |
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