HCSGD entry for PLOD3
1. General information
| Official gene symbol | PLOD3 |
|---|---|
| Entrez ID | 8985 |
| Gene full name | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 |
| Other gene symbols | LH3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001886 | Endothelial cell morphogenesis | IEA | biological_process |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IEA TAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0008104 | Protein localization | IEA | biological_process |
| GO:0008475 | Procollagen-lysine 5-dioxygenase activity | IEA | molecular_function |
| GO:0021915 | Neural tube development | IEA | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030199 | Collagen fibril organization | IEA | biological_process |
| GO:0030867 | Rough endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0031418 | L-ascorbic acid binding | IEA | molecular_function |
| GO:0032870 | Cellular response to hormone stimulus | IEA | biological_process |
| GO:0033823 | Procollagen glucosyltransferase activity | IEA TAS | molecular_function |
| GO:0042311 | Vasodilation | IEA | biological_process |
| GO:0048730 | Epidermis morphogenesis | IEA | biological_process |
| GO:0050211 | Procollagen galactosyltransferase activity | TAS | molecular_function |
| GO:0060425 | Lung morphogenesis | IEA | biological_process |
| GO:0070831 | Basement membrane assembly | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1631295695 | 0.2156491661 | 0.7998758197 | 0.8952380104 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2346131427 |
| GSE13712_SHEAR | Down | -0.2028753169 |
| GSE13712_STATIC | Up | 0.0306998223 |
| GSE19018 | Up | 0.7867836555 |
| GSE19899_A1 | Down | -0.5656578339 |
| GSE19899_A2 | Up | 0.0541972090 |
| PubMed_21979375_A1 | Up | 1.1188028754 |
| PubMed_21979375_A2 | Up | 0.8851216551 |
| GSE35957 | Down | -0.8863459808 |
| GSE36640 | Down | -0.0252221195 |
| GSE54402 | Down | -0.1563456632 |
| GSE9593 | Up | 0.3081682023 |
| GSE43922 | Down | -0.0097071076 |
| GSE24585 | Down | -0.0954130047 |
| GSE37065 | Down | -0.3729245439 |
| GSE28863_A1 | Up | 0.2521088252 |
| GSE28863_A2 | Up | 0.5119072874 |
| GSE28863_A3 | Down | -0.0797989788 |
| GSE28863_A4 | Down | -0.4216199448 |
| GSE48662 | Up | 0.2714244251 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vitamin C | DB00126 | NUTR00001 | APRD00084 | EXPT00568 | DB09541 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT000169 | Luciferase reporter assay//Quantitative proteomic approach | Functional MTI | 19253296 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002723 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002723 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-320b | MIMAT0005792 | MIRT036230 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
