HCSGD entry for FGD3

1. General information

Official gene symbolFGD3
Entrez ID89846
Gene full nameFYVE, RhoGEF and PH domain containing 3
Other gene symbolsZFYVE5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleISScellular_component
GO:0005085Guanyl-nucleotide exchange factor activityISSmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005737CytoplasmISScellular_component
GO:0005794Golgi apparatusISScellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0007010Cytoskeleton organizationISSbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0008360Regulation of cell shapeISSbiological_process
GO:0030027LamellipodiumISScellular_component
GO:0030036Actin cytoskeleton organizationISSbiological_process
GO:0031267Small GTPase bindingISSmolecular_function
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043088Regulation of Cdc42 GTPase activityISSbiological_process
GO:0046847Filopodium assemblyISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65846432890.90198526270.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1105071440
GSE13712_SHEARUp0.0498879746
GSE13712_STATICDown-0.0970356507
GSE19018Up0.1140643876
GSE19899_A1Up0.0908844498
GSE19899_A2Up0.0325009532
PubMed_21979375_A1Up0.1286434114
PubMed_21979375_A2Down-0.0608696725
GSE35957Up0.1312337750
GSE36640Up0.0137305160
GSE54402Up0.0955093400
GSE9593Down-0.0061289108
GSE43922Up0.0369255273
GSE24585Up0.1063812308
GSE37065Down-0.1411914824
GSE28863_A1Down-0.1779728172
GSE28863_A2Down-0.1019152329
GSE28863_A3Up0.2281808274
GSE28863_A4Up0.1242699588
GSE48662Up0.0413854466

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017809MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.