HCSGD entry for CHRFAM7A

1. General information

Official gene symbolCHRFAM7A
Entrez ID89832
Gene full nameCHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
Other gene symbolsCHRNA7 CHRNA7-DR1 D-10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001988Positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressureIEAbiological_process
GO:0004889Acetylcholine-activated cation-selective channel activityIEAmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0006816Calcium ion transportIEAbiological_process
GO:0006897EndocytosisIEAbiological_process
GO:0007271Synaptic transmission, cholinergicIEAbiological_process
GO:0007613MemoryIEAbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0008179Adenylate cyclase bindingIEAmolecular_function
GO:0008306Associative learningIEAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0014061Regulation of norepinephrine secretionIEAbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0019228Neuronal action potentialIEAbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0030317Sperm motilityIEAbiological_process
GO:0030424AxonIEAcellular_component
GO:0030426Growth coneIEAcellular_component
GO:0032094Response to foodIEAbiological_process
GO:0032225Regulation of synaptic transmission, dopaminergicIEAbiological_process
GO:0032279Asymmetric synapseIEAcellular_component
GO:0032691Negative regulation of interleukin-1 beta productionIEAbiological_process
GO:0032715Negative regulation of interleukin-6 productionIEAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIEAbiological_process
GO:0035095Behavioral response to nicotineIEAbiological_process
GO:0042110T cell activationIEAbiological_process
GO:0042113B cell activationIEAbiological_process
GO:0042166Acetylcholine bindingIEAmolecular_function
GO:0042416Dopamine biosynthetic processIEAbiological_process
GO:0042734Presynaptic membraneIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043197Dendritic spineIEAcellular_component
GO:0043198Dendritic shaftIEAcellular_component
GO:0045121Membrane raftIEAcellular_component
GO:0048149Behavioral response to ethanolIEAbiological_process
GO:0050728Negative regulation of inflammatory responseIEAbiological_process
GO:0051117ATPase bindingIEAmolecular_function
GO:0060112Generation of ovulation cycle rhythmIEAbiological_process
GO:0097110Scaffold protein bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.32448842370.67348103800.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.4605651728
GSE28863_A2Down-0.3533729718
GSE28863_A3Up0.4912023254
GSE28863_A4Up0.3836196780
GSE48662Up0.0256570376

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NicotineDB00184 APRD00200 | EXPT02315 | DB09463
TalbutalDB00306 APRD01333
PentobarbitalDB00312 APRD01174
MetharbitalDB00463 APRD00757
DextromethorphanDB00514 APRD00655
GalantamineDB00674 APRD00206 | EXPT01628
PrimidoneDB00794 APRD00549
VareniclineDB01273 -
AmobarbitalDB01351 -
AprobarbitalDB01352 -
ButethalDB01353 -
HeptabarbitalDB01354 -
HexobarbitalDB01355 EXPT03301
BarbitalDB01483 -
Barbituric acid derivativeDB01496 -
GTS-21DB05708 -
RPI-78MDB05740 -
CytisineDB09028 -
(3-EXO)-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8,8-DIMETHYL-8-AZONIABICYCLO[3.2.1]OCTANEDB07494 -
EPIBATIDINEDB07720 -
(E)-imidaclopridDB07980 -
{(2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene}cyanamideDB08620 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017997MicroarrayFunctional MTI (Weak)18185580
hsa-miR-181a-5pMIMAT0000256MIRT025040MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.