HCSGD entry for USP13
1. General information
| Official gene symbol | USP13 |
|---|---|
| Entrez ID | 8975 |
| Gene full name | ubiquitin specific peptidase 13 (isopeptidase T-3) |
| Other gene symbols | ISOT3 IsoT-3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004197 | Cysteine-type endopeptidase activity | IMP | molecular_function |
| GO:0004221 | Ubiquitin thiolesterase activity | IDA IEA | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006355 | Regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0006914 | Autophagy | IEA | biological_process |
| GO:0008242 | Omega peptidase activity | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008283 | Cell proliferation | IMP | biological_process |
| GO:0010506 | Regulation of autophagy | IDA | biological_process |
| GO:0030318 | Melanocyte differentiation | TAS | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0043130 | Ubiquitin binding | IDA | molecular_function |
| GO:0050821 | Protein stabilization | IDA | biological_process |
| GO:0070536 | Protein K63-linked deubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9920189165 | 0.0015322176 | 0.9999902473 | 0.0759500942 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3285029770 |
| GSE13712_SHEAR | Down | -0.1637672084 |
| GSE13712_STATIC | Down | -0.2154683746 |
| GSE19018 | Down | -0.2007433681 |
| GSE19899_A1 | Down | -0.5877634766 |
| GSE19899_A2 | Down | -1.3026730227 |
| PubMed_21979375_A1 | Down | -2.0611933897 |
| PubMed_21979375_A2 | Down | -1.5834312476 |
| GSE35957 | Down | -0.2538100916 |
| GSE36640 | Down | -1.7649106533 |
| GSE54402 | Down | -0.4503948707 |
| GSE9593 | Down | -0.0167200670 |
| GSE43922 | Down | -0.8297783917 |
| GSE24585 | Down | -0.3646102618 |
| GSE37065 | Down | -0.1160292517 |
| GSE28863_A1 | Up | 0.3701937807 |
| GSE28863_A2 | Up | 0.3782591816 |
| GSE28863_A3 | Down | -0.6105934194 |
| GSE28863_A4 | Down | -0.1254768854 |
| GSE48662 | Down | -0.6720577181 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049674 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
