HCSGD entry for P4HA2
1. General information
| Official gene symbol | P4HA2 |
|---|---|
| Entrez ID | 8974 |
| Gene full name | prolyl 4-hydroxylase, alpha polypeptide II |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004656 | Procollagen-proline 4-dioxygenase activity | IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | IEA | cellular_component |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0016702 | Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | IEA | molecular_function |
| GO:0018401 | Peptidyl-proline hydroxylation to 4-hydroxy-L-proline | IEA | biological_process |
| GO:0031418 | L-ascorbic acid binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0137791421 | 0.9882043843 | 0.2929570275 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1071599711 |
| GSE13712_SHEAR | Down | -0.0012760792 |
| GSE13712_STATIC | Up | 0.0632051419 |
| GSE19018 | Up | 1.5169885519 |
| GSE19899_A1 | Up | 0.5096601247 |
| GSE19899_A2 | Up | 0.3859613366 |
| PubMed_21979375_A1 | Up | 0.2453621600 |
| PubMed_21979375_A2 | Up | 0.5730640897 |
| GSE35957 | Down | -0.0672379093 |
| GSE36640 | Up | 0.0829204369 |
| GSE54402 | Up | 0.0822267310 |
| GSE9593 | Up | 0.3493491803 |
| GSE43922 | Up | 0.3497000497 |
| GSE24585 | Up | 0.2419615051 |
| GSE37065 | Up | 0.1206301162 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.7030285341 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005168 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021377 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
