HCSGD entry for CHRNA6

1. General information

Official gene symbolCHRNA6
Entrez ID8973
Gene full namecholinergic receptor, nicotinic, alpha 6 (neuronal)
Other gene symbolsCHNRA6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004889Acetylcholine-activated cation-selective channel activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005892Acetylcholine-gated channel complexIEAcellular_component
GO:0006810TransportTASbiological_process
GO:0006812Cation transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0014059Regulation of dopamine secretionIEAbiological_process
GO:0015464Acetylcholine receptor activityTASmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0051899Membrane depolarizationIEAbiological_process
GO:0055085Transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83326410470.46794451960.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1556901161
GSE13712_SHEARDown-0.1364743422
GSE13712_STATICDown-0.1470447132
GSE19018Down-0.1237250757
GSE19899_A1Down-0.1452205750
GSE19899_A2Down-0.0525484536
PubMed_21979375_A1Up0.0642805817
PubMed_21979375_A2Down-0.3115893851
GSE35957Up0.1413859202
GSE36640Up0.1076491092
GSE54402Up0.0288012896
GSE9593Up0.0305183267
GSE43922Up0.0118004408
GSE24585Up0.3541860486
GSE37065Up0.0195241184
GSE28863_A1Down-0.1790006652
GSE28863_A2Down-0.0375547110
GSE28863_A3Up0.2628725674
GSE28863_A4Up0.1237614821
GSE48662Down-0.0787683297

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NicotineDB00184 APRD00200 | EXPT02315 | DB09463
GalantamineDB00674 APRD00206 | EXPT01628
VareniclineDB01273 -
CytisineDB09028 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.