HCSGD entry for CCND2
1. General information
| Official gene symbol | CCND2 |
|---|---|
| Entrez ID | 894 |
| Gene full name | cyclin D2 |
| Other gene symbols | KIAK0002 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000307 | Cyclin-dependent protein kinase holoenzyme complex | IDA | cellular_component |
| GO:0000785 | Chromatin | IDA | cellular_component |
| GO:0001934 | Positive regulation of protein phosphorylation | IDA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0045737 | Positive regulation of cyclin-dependent protein kinase activity | IDA | biological_process |
| GO:0051301 | Cell division | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000210098 | 0.6427901941 | 0.0149063830 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.9265820680 |
| GSE13712_SHEAR | Down | -0.2890798655 |
| GSE13712_STATIC | Down | -0.2579621530 |
| GSE19018 | Down | -0.1487223449 |
| GSE19899_A1 | Up | 0.8573231136 |
| GSE19899_A2 | Up | 2.5026618162 |
| PubMed_21979375_A1 | Up | 3.5947678733 |
| PubMed_21979375_A2 | Up | 3.4501311850 |
| GSE35957 | Up | 2.2621266987 |
| GSE36640 | Up | 7.4299828743 |
| GSE54402 | Up | 0.2617760397 |
| GSE9593 | Up | 0.1729791094 |
| GSE43922 | Up | 1.9118643823 |
| GSE24585 | Down | -1.5870190069 |
| GSE37065 | Up | 0.6411269411 |
| GSE28863_A1 | Up | 0.1828215164 |
| GSE28863_A2 | Up | 1.7799769557 |
| GSE28863_A3 | Up | 0.4318234165 |
| GSE28863_A4 | Up | 0.0160112037 |
| GSE48662 | Up | 0.8101403617 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26a-5p | MIMAT0000082 | MIRT000112 | Luciferase reporter assay//Western blot | Functional MTI | 19524505 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000285 | Luciferase reporter assay | Functional MTI | 19549910 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000285 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT003431 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-302b-3p | MIMAT0000715 | MIRT003555 | Luciferase reporter assay//Western blot | Functional MTI | 18930031 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT003835 | Luciferase reporter assay | Functional MTI | 17699775 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT003835 | qRT-PCR | Functional MTI (Weak) | 17942906 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT005478 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20418948 |
| hsa-miR-302d-3p | MIMAT0000718 | MIRT005673 | Luciferase reporter assay//Microarray//Northern blot//Western blot | Functional MTI | 21062975 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT005848 | Luciferase reporter assay | Functional MTI | 21283765 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT005848 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT005854 | Luciferase reporter assay | Functional MTI | 21283765 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT005862 | Luciferase reporter assay | Functional MTI | 21283765 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT007064 | Flow//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22848417 |
| hsa-miR-206 | MIMAT0000462 | MIRT007217 | Luciferase reporter assay | Functional MTI | 23348698 |
| hsa-miR-206 | MIMAT0000462 | MIRT007217 | Luciferase reporter assay | Functional MTI | 23466356 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018710 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026074 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031274 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036978 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037251 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038097 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040184 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042861 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-342-3p | MIMAT0000753 | MIRT043702 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043920 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-301a-3p | MIMAT0000688 | MIRT044222 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044790 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-302b-3p | MIMAT0000715 | 1 | hsa-miR-302b | 18930031 | |||
| hsa-miR-302d-3p | MIMAT0000718 | 1 | hsa-miR-302d | {Western blot} | {overexpression by miRNA mimics tranfection} | 21062975 | |
| hsa-miR-302d-3p | MIMAT0000718 | 2 | hsa-miR-302d | {Western blot} | {overexpression by miRNA mimics tranfection} | 21062975 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25540416 | EBNA3A was at MYC, CDKN2A/B, CCND2, CXCL9/10, and BCL2, together with RUNX3, BATF, IRF4, and SPI1 |
| 21047732 | Paradoxically, G(1)-S phase genes such as MYC, CDK4, CDK6, CCND1, and CCND2 were strongly downregulated, in line with the observed G(1) arrest |
| 20622962 | Downregulated genes included cyclin D2, keratin 8, insulin-like growth factor 2 (IGF2), natriuretic peptide precursor B (NPPB) and cellular retinoic acid binding protein 2 (CRABP2) |
| 19693768 | Fifteen cell-cycle regulator genes were investigated and only three genes (APC, CCND2, and BMP2) were differentially expressed between bMSC and oMSC |
| 10951233 | Cyclin D2, which is regulated by extracellular-signal-regulated kinase and functions to promote cell cycle progression, was reduced 50% in old skin compared with young skin |
| 9584157 | Increased expression of cyclin D2 during multiple states of growth arrest in primary and established cells |
| 9584157 | Cyclin D2 is a member of the family of D-type cyclins that is implicated in cell cycle regulation, differentiation, and oncogenic transformation |
| 9584157 | To better understand the role of this cyclin in the control of cell proliferation, cyclin D2 expression was monitored under various growth conditions in primary human and established murine fibroblasts |
| 9584157 | In different states of cellular growth arrest initiated by contact inhibition, serum starvation, or cellular senescence, marked increases (5- to 20-fold) were seen in the expression levels of cyclin D2 mRNA and protein |
| 9584157 | Indirect immunofluorescence studies showed that cyclin D2 protein localized to the nucleus in G0, suggesting a nuclear function for cyclin D2 in quiescent cells |
| 9584157 | Cyclin D2 was also found to be associated with the cyclin-dependent kinases CDK2 and CDK4 but not CDK6 during growth arrest |
| 9584157 | Transient transfection and needle microinjection of cyclin D2 expression constructs demonstrated that overexpression of cyclin D2 protein efficiently inhibited cell cycle progression and DNA synthesis |
| 9584157 | These data suggest that in addition to a role in promoting cell cycle progression through phosphorylation of retinoblastoma family proteins in some cell systems, cyclin D2 may contribute to the induction and/or maintenance of a nonproliferative state, possibly through sequestration of the CDK2 catalytic subunit |
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