HCSGD entry for SKAP2
1. General information
| Official gene symbol | SKAP2 |
|---|---|
| Entrez ID | 8935 |
| Gene full name | src kinase associated phosphoprotein 2 |
| Other gene symbols | PRAP RA70 SAPS SCAP2 SKAP-HOM SKAP55R |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006461 | Protein complex assembly | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0009967 | Positive regulation of signal transduction | TAS | biological_process |
| GO:0042113 | B cell activation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6273756012 | 0.1760008548 | 0.9999902473 | 0.8118679460 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1235600467 |
| GSE13712_SHEAR | Up | 0.0731393760 |
| GSE13712_STATIC | Up | 0.1552915548 |
| GSE19018 | Up | 0.4093343688 |
| GSE19899_A1 | Down | -0.4485776890 |
| GSE19899_A2 | Down | -0.4930219281 |
| PubMed_21979375_A1 | Down | -0.3574756675 |
| PubMed_21979375_A2 | Down | -0.5860181231 |
| GSE35957 | Up | 0.1566766305 |
| GSE36640 | Down | -0.2492412485 |
| GSE54402 | Down | -0.2043298587 |
| GSE9593 | Up | 0.2197758389 |
| GSE43922 | Down | -0.1395852470 |
| GSE24585 | Up | 0.3004286622 |
| GSE37065 | Up | 0.6857652684 |
| GSE28863_A1 | Down | -0.1884110417 |
| GSE28863_A2 | Up | 0.0343727612 |
| GSE28863_A3 | Down | -0.0630378815 |
| GSE28863_A4 | Down | -0.0460073271 |
| GSE48662 | Up | 0.0671989904 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | MIRT003875 | Microarray//qRT-PCR | Functional MTI (Weak) | 18362358 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT004369 | Microarray//qRT-PCR | Functional MTI (Weak) | 18362358 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017252 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-484 | MIMAT0002174 | MIRT042017 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | NA | hsa-miR-15a | 18362358 | |||
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | 18362358 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
