HCSGD entry for MBD2
1. General information
| Official gene symbol | MBD2 |
|---|---|
| Entrez ID | 8932 |
| Gene full name | methyl-CpG binding domain protein 2 |
| Other gene symbols | DMTase NY-CO-41 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000118 | Histone deacetylase complex | IEA | cellular_component |
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000792 | Heterochromatin | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003696 | Satellite DNA binding | TAS | molecular_function |
| GO:0003729 | MRNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA NAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008327 | Methyl-CpG binding | IDA NAS | molecular_function |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0030177 | Positive regulation of Wnt signaling pathway | IEA | biological_process |
| GO:0035197 | SiRNA binding | IEA | molecular_function |
| GO:0042127 | Regulation of cell proliferation | IEA | biological_process |
| GO:0042711 | Maternal behavior | IEA | biological_process |
| GO:0043623 | Cellular protein complex assembly | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0070742 | C2H2 zinc finger domain binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8413497929 | 0.4720796322 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1544717838 |
| GSE13712_SHEAR | Down | -0.0257360595 |
| GSE13712_STATIC | Up | 0.0673891114 |
| GSE19018 | Up | 0.1516773678 |
| GSE19899_A1 | Up | 0.0289486214 |
| GSE19899_A2 | Up | 0.0440786243 |
| PubMed_21979375_A1 | Down | -0.1427650507 |
| PubMed_21979375_A2 | Up | 0.0147230364 |
| GSE35957 | Up | 0.0849578401 |
| GSE36640 | Down | -0.1033320964 |
| GSE54402 | Down | -0.1192180168 |
| GSE9593 | Down | -0.0004861608 |
| GSE43922 | Down | -0.0167854196 |
| GSE24585 | Down | -0.3169278189 |
| GSE37065 | Down | -0.0017789138 |
| GSE28863_A1 | Up | 0.2916959400 |
| GSE28863_A2 | Up | 0.1131956555 |
| GSE28863_A3 | Up | 0.0040052838 |
| GSE28863_A4 | Up | 0.1451865732 |
| GSE48662 | Down | -0.2468914396 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019870 | Microarray | Functional MTI (Weak) | 20215506 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18723031 | The levels of DNMT3b and methyl-CpG binding protein 2 (MeCP2) increased in both mid-aged and replicative senescent cells, while DNMT3a and MBD2 were upregulated in the mid-aged cells |
| 18723031 | Additionally, the expression for DNMTs, MBD2 and MeCP2 was increased rapidly upon H(2)O(2) treatment |
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