HCSGD entry for PHOX2B

1. General information

Official gene symbolPHOX2B
Entrez ID8929
Gene full namepaired-like homeobox 2b
Other gene symbolsNBLST2 NBPhox PMX2B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000790Nuclear chromatinIDAcellular_component
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0001764Neuron migrationISSbiological_process
GO:0002087Regulation of respiratory gaseous exchange by neurological system processISSbiological_process
GO:0003357Noradrenergic neuron differentiationIC ISSbiological_process
GO:0003358Noradrenergic neuron developmentISSbiological_process
GO:0003360Brainstem developmentIEPbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0010001Glial cell differentiationISSbiological_process
GO:0010468Regulation of gene expressionISSbiological_process
GO:0010971Positive regulation of G2/M transition of mitotic cell cycleISSbiological_process
GO:0021533Cell differentiation in hindbrainISSbiological_process
GO:0021723Medullary reticular formation developmentISSbiological_process
GO:0021934Hindbrain tangential cell migrationISSbiological_process
GO:0035914Skeletal muscle cell differentiationIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0048483Autonomic nervous system developmentIMPbiological_process
GO:0048484Enteric nervous system developmentIEPbiological_process
GO:0048485Sympathetic nervous system developmentISSbiological_process
GO:0048486Parasympathetic nervous system developmentISSbiological_process
GO:0048839Inner ear developmentISSbiological_process
GO:0048894Efferent axon development in a lateral line nerveISSbiological_process
GO:0060541Respiratory system developmentISSbiological_process
GO:0061452Retrotrapezoid nucleus neuron differentiationISSbiological_process
GO:0061549Sympathetic ganglion developmentISSbiological_process
GO:0071157Negative regulation of cell cycle arrestISSbiological_process
GO:0071542Dopaminergic neuron differentiationIC ISSbiological_process
GO:0071773Cellular response to BMP stimulusISSbiological_process
GO:1901166Neural crest cell migration involved in autonomic nervous system developmentISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.59830042170.83930447550.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1441876201
GSE13712_SHEARUp0.0976144916
GSE13712_STATICUp0.0067816592
GSE19018Up0.3985067096
GSE19899_A1Up0.0982769564
GSE19899_A2Down-0.0795554821
PubMed_21979375_A1Up0.0139650850
PubMed_21979375_A2Down-0.0552657933
GSE35957Up0.0199754224
GSE36640Up0.0998610179
GSE54402Up0.0472817454
GSE9593Down-0.3164359473
GSE43922Up0.0163728024
GSE24585Down-0.0347445960
GSE37065Up0.0060607653
GSE28863_A1Down-0.1221693150
GSE28863_A2Down-0.0316125994
GSE28863_A3Up0.2264684896
GSE28863_A4Up0.0540975003
GSE48662Up0.0761077573

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.