HCSGD entry for HERC1
1. General information
| Official gene symbol | HERC1 |
|---|---|
| Entrez ID | 8925 |
| Gene full name | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 |
| Other gene symbols | p532 p619 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0005086 | ARF guanyl-nucleotide exchange factor activity | TAS | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006810 | Transport | IEA | biological_process |
| GO:0010507 | Negative regulation of autophagy | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0021702 | Cerebellar Purkinje cell differentiation | IEA | biological_process |
| GO:0031175 | Neuron projection development | IEA | biological_process |
| GO:0043087 | Regulation of GTPase activity | TAS | biological_process |
| GO:0050885 | Neuromuscular process controlling balance | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1314650317 | 0.5293156225 | 0.7359068042 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0294162418 |
| GSE13712_SHEAR | Down | -0.1717232288 |
| GSE13712_STATIC | Down | -0.1528728115 |
| GSE19018 | Down | -0.0145808940 |
| GSE19899_A1 | Up | 0.0871151009 |
| GSE19899_A2 | Down | -0.2773536288 |
| PubMed_21979375_A1 | Down | -0.2951591477 |
| PubMed_21979375_A2 | Down | -0.0812786142 |
| GSE35957 | Up | 0.0906746162 |
| GSE36640 | Up | 0.2498435799 |
| GSE54402 | Up | 0.0440158274 |
| GSE9593 | Down | -0.0124124015 |
| GSE43922 | Down | -0.1101866579 |
| GSE24585 | Up | 0.0396311036 |
| GSE37065 | Down | -0.1695791716 |
| GSE28863_A1 | Up | 1.8423404818 |
| GSE28863_A2 | Up | 1.4592147553 |
| GSE28863_A3 | Down | -0.1419845534 |
| GSE28863_A4 | Down | -0.0675632962 |
| GSE48662 | Down | -0.0308386070 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-455-3p | MIMAT0004784 | MIRT037896 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041520 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042828 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT048986 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050724 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
