HCSGD entry for HERC2
1. General information
| Official gene symbol | HERC2 |
|---|---|
| Entrez ID | 8924 |
| Gene full name | HECT and RLD domain containing E3 ubiquitin protein ligase 2 |
| Other gene symbols | D15F37S1 SHEP1 jdf2 p528 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005085 | Guanyl-nucleotide exchange factor activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005814 | Centriole | IEA | cellular_component |
| GO:0006281 | DNA repair | IDA | biological_process |
| GO:0006886 | Intracellular protein transport | NAS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0032183 | SUMO binding | IDA | molecular_function |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IBA | biological_process |
| GO:0043087 | Regulation of GTPase activity | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4260701075 | 0.4690179932 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0293192763 |
| GSE13712_SHEAR | Up | 0.0303471001 |
| GSE13712_STATIC | Down | -0.0811958321 |
| GSE19018 | Down | -0.3243955476 |
| GSE19899_A1 | Down | -0.2400336420 |
| GSE19899_A2 | Down | -0.1281780403 |
| PubMed_21979375_A1 | Down | -0.7090106526 |
| PubMed_21979375_A2 | Up | 0.4881469882 |
| GSE35957 | Up | 0.7569506952 |
| GSE36640 | Down | -0.0342541779 |
| GSE54402 | Up | 0.0325652051 |
| GSE9593 | Up | 0.0149499792 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.0281833583 |
| GSE28863_A2 | Up | 0.0155150722 |
| GSE28863_A3 | Down | -0.0207861606 |
| GSE28863_A4 | Up | 0.0317951603 |
| GSE48662 | Up | 0.2611247145 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023773 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026472 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037101 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041348 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042693 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27259994 | Methods and Results-Co-immunoprecipitation assay demonstrated that SIRT1, via its amino-terminus, binds to the DOC domain of HERC2 [HECT and RLD domain containing E3 ubiquitin protein ligase 2], which then ubiquitinates LKB1 in the nuclear compartment of endothelial cells |
| 27259994 | Knocking down either SIRT1 or HERC2 results in an increased association of LKB1 with the positive regulatory elements of TGFbeta1 promoter |
| 27259994 | Lentiviral-mediated knockdown of HERC2 abolishes the beneficial effects of endothelial SIRT1 on both arterial remodeling and arterial blood pressure control |
| 27259994 | Conclusion-By downregulating acetylated LKB1 protein via HERC2, SIRT1 fine-tunes the crosstalk between endothelial and vascular smooth muscle cells to prevent adverse arterial remodeling and maintain vascular homeostasis |
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