HCSGD entry for TIMELESS
1. General information
| Official gene symbol | TIMELESS |
|---|---|
| Entrez ID | 8914 |
| Gene full name | timeless circadian clock |
| Other gene symbols | TIM TIM1 hTIM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0002009 | Morphogenesis of an epithelium | ISS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IC IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007623 | Circadian rhythm | ISS | biological_process |
| GO:0009582 | Detection of abiotic stimulus | TAS | biological_process |
| GO:0009628 | Response to abiotic stimulus | TAS | biological_process |
| GO:0009790 | Embryo development | IEA | biological_process |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0042127 | Regulation of cell proliferation | IMP | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0044770 | Cell cycle phase transition | IMP | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0048754 | Branching morphogenesis of an epithelial tube | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9487019756 | 0.0053898940 | 0.9999902473 | 0.1487079665 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1753462450 |
| GSE13712_SHEAR | Down | -0.0543838108 |
| GSE13712_STATIC | Down | -0.2917588874 |
| GSE19018 | Down | -0.1053279590 |
| GSE19899_A1 | Down | -0.2259658395 |
| GSE19899_A2 | Down | -1.7601027721 |
| PubMed_21979375_A1 | Down | -1.4550168114 |
| PubMed_21979375_A2 | Down | -1.7254211458 |
| GSE35957 | Down | -0.8690943867 |
| GSE36640 | Down | -2.0477603765 |
| GSE54402 | Down | -0.1779323816 |
| GSE9593 | Down | -0.5993690279 |
| GSE43922 | Down | -0.5822166191 |
| GSE24585 | Up | 0.5442501835 |
| GSE37065 | Up | 0.0030127674 |
| GSE28863_A1 | Up | 0.0566723928 |
| GSE28863_A2 | Up | 0.6420474354 |
| GSE28863_A3 | Down | -0.1343917950 |
| GSE28863_A4 | Up | 0.1246948768 |
| GSE48662 | Down | -0.7105042777 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-320b | MIMAT0005792 | MIRT036201 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036827 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039980 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041838 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043049 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047095 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-146a-5p | MIMAT0000449 | NA | hsa-miR-146a | 19944095 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
