HCSGD entry for EIF2B5

1. General information

Official gene symbolEIF2B5
Entrez ID8893
Gene full nameeukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
Other gene symbolsCACH CLE EIF-2B EIF2Bepsilon LVWM
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001541Ovarian follicle developmentIMPbiological_process
GO:0003743Translation initiation factor activityIDA NASmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityIDA IEA IMP ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA ISScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005851Eukaryotic translation initiation factor 2B complexIDAcellular_component
GO:0006412TranslationTASbiological_process
GO:0006413Translational initiationIDA TASbiological_process
GO:0009408Response to heatIMP ISS TASbiological_process
GO:0009749Response to glucoseIEA ISSbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0014002Astrocyte developmentIMPbiological_process
GO:0014003Oligodendrocyte developmentIMPbiological_process
GO:0031369Translation initiation factor bindingIEA ISSmolecular_function
GO:0032057Negative regulation of translational initiation in response to stressIEA ISSbiological_process
GO:0034976Response to endoplasmic reticulum stressIMPbiological_process
GO:0035690Cellular response to drugIDAbiological_process
GO:0042552MyelinationIMPbiological_process
GO:0043087Regulation of GTPase activityIDA IMP ISSbiological_process
GO:0043434Response to peptide hormoneIEA ISSbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045948Positive regulation of translational initiationISSbiological_process
GO:0048708Astrocyte differentiationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18271268190.69033339160.83645970101.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1791963239
GSE13712_SHEARUp0.0056729890
GSE13712_STATICUp0.0321059463
GSE19018Down-0.1363463624
GSE19899_A1Up0.2727063509
GSE19899_A2Up0.5936006314
PubMed_21979375_A1Up0.1388171220
PubMed_21979375_A2Up0.5743280848
GSE35957Down-0.2820795733
GSE36640Up0.2241598193
GSE54402Up0.4024034226
GSE9593Down-0.5112135230
GSE43922Up0.0588002340
GSE24585Down-0.3394161236
GSE37065Up0.2905500856
GSE28863_A1Up0.0771992552
GSE28863_A2Up0.2347833324
GSE28863_A3Down-0.5398377081
GSE28863_A4Down-0.1796295426
GSE48662Down-0.0127352119

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020497ProteomicsFunctional MTI (Weak)18668040
hsa-miR-16-5pMIMAT0000069MIRT031470ProteomicsFunctional MTI (Weak)18668040
hsa-miR-760MIMAT0004957MIRT036792CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.