HCSGD entry for MCM3AP
1. General information
| Official gene symbol | MCM3AP |
|---|---|
| Entrez ID | 8888 |
| Gene full name | minichromosome maintenance complex component 3 associated protein |
| Other gene symbols | GANP MAP80 SAC3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002376 | Immune system process | IEA | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005643 | Nuclear pore | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0006606 | Protein import into nucleus | TAS | biological_process |
| GO:0016746 | Transferase activity, transferring acyl groups | IEA | molecular_function |
| GO:0051028 | MRNA transport | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2049568102 | 0.9327773869 | 0.8727824300 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0173483998 |
| GSE13712_SHEAR | Up | 0.0097407573 |
| GSE13712_STATIC | Down | -0.0263615317 |
| GSE19018 | Down | -0.0360095446 |
| GSE19899_A1 | Up | 0.0705490869 |
| GSE19899_A2 | Up | 0.0586118321 |
| PubMed_21979375_A1 | Down | -0.4185054741 |
| PubMed_21979375_A2 | Up | 0.1668550745 |
| GSE35957 | Up | 0.0548411415 |
| GSE36640 | Down | -0.0435536438 |
| GSE54402 | Up | 0.1787770454 |
| GSE9593 | Up | 0.0352070444 |
| GSE43922 | Up | 0.0871572880 |
| GSE24585 | Down | -0.0528485729 |
| GSE37065 | Down | -0.0971623046 |
| GSE28863_A1 | Up | 0.4500024946 |
| GSE28863_A2 | Up | 0.4662863233 |
| GSE28863_A3 | Up | 0.3697079098 |
| GSE28863_A4 | Up | 0.2224190289 |
| GSE48662 | Down | -0.0586666138 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT039880 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042228 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046814 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050147 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052573 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-3200-3p | MIMAT0015085 | MIRT052817 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19686285 | Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas |
| 19686285 | Here, we found that the level of germinal center-associated nuclear protein (GANP), a mammalian homologue of yeast Sac3, was markedly decreased in MGs with a poor prognosis; and thus we explored the effect of its decrease on cell-cycle progression of MG cell lines |
| 19686285 | These results suggest that GANP protects cells from cellular senescence caused by DNA damage and that a significant decrease in GANP expression leads to malignancy by generating hyperploidy and CIN |
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