HCSGD entry for ARHGEF7

1. General information

Official gene symbolARHGEF7
Entrez ID8874
Gene full nameRho guanine nucleotide exchange factor (GEF) 7
Other gene symbolsBETA-PIX COOL-1 COOL1 Nbla10314 P50 P50BP P85 P85COOL1 P85SPR PAK3 PIXB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIEAcellular_component
GO:0005085Guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005925Focal adhesionIEAcellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007399Nervous system developmentIEAbiological_process
GO:0019901Protein kinase bindingIEA IPImolecular_function
GO:0030027LamellipodiumIEA ISScellular_component
GO:0030032Lamellipodium assemblyIEA ISSbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0042059Negative regulation of epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0043005Neuron projectionIDAcellular_component
GO:0043025Neuronal cell bodyIDAcellular_component
GO:0043065Positive regulation of apoptotic processIMP TASbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043547Positive regulation of GTPase activityIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.26541371530.97106418450.96105855341.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0109027010
GSE13712_SHEARUp0.1912818090
GSE13712_STATICDown-0.1913307679
GSE19018Up0.0249607926
GSE19899_A1Up0.0645421453
GSE19899_A2Up0.1461662111
PubMed_21979375_A1Up0.1311458583
PubMed_21979375_A2Up0.4131788804
GSE35957Down-0.0269614092
GSE36640Up0.1514874771
GSE54402Up0.1345330513
GSE9593Up0.0433523925
GSE43922Up0.0371861126
GSE24585Up0.1323358011
GSE37065Up0.1272873662
GSE28863_A1Up0.2435377771
GSE28863_A2Up0.1768433267
GSE28863_A3Up0.1624272123
GSE28863_A4Up0.0772932073
GSE48662Up0.0196359854

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-24-3pMIMAT0000080MIRT030425MicroarrayFunctional MTI (Weak)19748357
hsa-miR-18a-3pMIMAT0002891MIRT040805CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050571CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050964CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.