HCSGD entry for APLN
1. General information
| Official gene symbol | APLN |
|---|---|
| Entrez ID | 8862 |
| Gene full name | apelin |
| Other gene symbols | APEL XNPEP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002026 | Regulation of the force of heart contraction | IEA | biological_process |
| GO:0005102 | Receptor binding | TAS | molecular_function |
| GO:0005179 | Hormone activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007595 | Lactation | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0031652 | Positive regulation of heat generation | IEA | biological_process |
| GO:0031704 | Apelin receptor binding | IEA | molecular_function |
| GO:0042327 | Positive regulation of phosphorylation | IEA | biological_process |
| GO:0042756 | Drinking behavior | IEA | biological_process |
| GO:0043576 | Regulation of respiratory gaseous exchange | IEA | biological_process |
| GO:0045776 | Negative regulation of blood pressure | IEA | biological_process |
| GO:0045906 | Negative regulation of vasoconstriction | IEA | biological_process |
| GO:0045909 | Positive regulation of vasodilation | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0051461 | Positive regulation of corticotropin secretion | IEA | biological_process |
| GO:0051466 | Positive regulation of corticotropin-releasing hormone secretion | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2241284450 | 0.5703253714 | 0.9046460702 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1267708181 |
| GSE13712_SHEAR | Up | 0.3356368360 |
| GSE13712_STATIC | Up | 0.0046129535 |
| GSE19018 | Up | 0.1322015182 |
| GSE19899_A1 | Down | -0.0137682809 |
| GSE19899_A2 | Up | 0.3684854772 |
| PubMed_21979375_A1 | Up | 0.1456255143 |
| PubMed_21979375_A2 | Up | 0.1472984524 |
| GSE35957 | Down | -0.5716982319 |
| GSE36640 | Down | -0.5261636294 |
| GSE54402 | Down | -0.1517226553 |
| GSE9593 | Down | -0.0931086845 |
| GSE43922 | Up | 0.1508659386 |
| GSE24585 | Down | -0.1041685664 |
| GSE37065 | Down | -0.1068780997 |
| GSE28863_A1 | Up | 0.3860253266 |
| GSE28863_A2 | Up | 0.5301081037 |
| GSE28863_A3 | Up | 0.2673567979 |
| GSE28863_A4 | Down | -0.0931396688 |
| GSE48662 | Up | 0.5344856039 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30b-5p | MIMAT0000420 | MIRT046134 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047924 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
