HCSGD entry for ALDH1A2

1. General information

Official gene symbolALDH1A2
Entrez ID8854
Gene full namealdehyde dehydrogenase 1 family, member A2
Other gene symbolsRALDH(II) RALDH2 RALDH2-T
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001568Blood vessel developmentIEAbiological_process
GO:0001758Retinal dehydrogenase activityIEA ISSmolecular_function
GO:0001822Kidney developmentIEAbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0001936Regulation of endothelial cell proliferationIEAbiological_process
GO:0003007Heart morphogenesisIEAbiological_process
GO:00040283-chloroallyl aldehyde dehydrogenase activityIEA ISSmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006776Vitamin A metabolic processNASbiological_process
GO:0007494Midgut developmentIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0009855Determination of bilateral symmetryIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0009954Proximal/distal pattern formationIEAbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0014032Neural crest cell developmentIEAbiological_process
GO:0016331Morphogenesis of embryonic epitheliumIEAbiological_process
GO:0016620Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptorIEAmolecular_function
GO:0016918Retinal bindingIEA ISSmolecular_function
GO:0021915Neural tube developmentIMPbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0030182Neuron differentiationIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0030902Hindbrain developmentIEAbiological_process
GO:0031016Pancreas developmentIEAbiological_process
GO:0031076Embryonic camera-type eye developmentIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0033189Response to vitamin AIEAbiological_process
GO:0034097Response to cytokineIDAbiological_process
GO:0035115Embryonic forelimb morphogenesisIEAbiological_process
GO:0035799Ureter maturationIEAbiological_process
GO:0042572Retinol metabolic processIEAbiological_process
GO:0042573Retinoic acid metabolic processISSbiological_process
GO:0042574Retinal metabolic processIEAbiological_process
GO:00429049-cis-retinoic acid biosynthetic processIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0048384Retinoic acid receptor signaling pathwayIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0048566Embryonic digestive tract developmentIEAbiological_process
GO:0048738Cardiac muscle tissue developmentIEAbiological_process
GO:0060324Face developmentIEAbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.53905567040.80964654460.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0052838730
GSE13712_SHEARDown-0.7977270062
GSE13712_STATICUp0.3133592861
GSE19018Up0.1196656200
GSE19899_A1Down-0.0229082025
GSE19899_A2Up0.1125930238
PubMed_21979375_A1Down-0.0072968435
PubMed_21979375_A2Up0.0734585394
GSE35957Up0.0221818250
GSE36640Up0.0911660549
GSE54402Down-0.0150550526
GSE9593Up0.2907125918
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0059595515

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
Vitamin ADB00162 NUTR00007 | APRD00486

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020672ProteomicsFunctional MTI (Weak)18668040
hsa-miR-615-3pMIMAT0003283MIRT039966CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041305CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047601CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.