HCSGD entry for KSR1
1. General information
| Official gene symbol | KSR1 |
|---|---|
| Entrez ID | 8844 |
| Gene full name | kinase suppressor of ras 1 |
| Other gene symbols | KSR RSU2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IEA NAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005078 | MAP-kinase scaffold activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0007265 | Ras protein signal transduction | NAS | biological_process |
| GO:0031434 | Mitogen-activated protein kinase kinase binding | IEA | molecular_function |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0043410 | Positive regulation of MAPK cascade | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8877823069 | 0.2320551537 | 0.9999902473 | 0.9279738225 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1829631839 |
| GSE13712_SHEAR | Up | 0.0473813065 |
| GSE13712_STATIC | Up | 0.3326210760 |
| GSE19018 | Up | 0.0361618392 |
| GSE19899_A1 | Down | -0.3182509201 |
| GSE19899_A2 | Down | -0.3963942278 |
| PubMed_21979375_A1 | Down | -0.4203288926 |
| PubMed_21979375_A2 | Down | -0.1763165488 |
| GSE35957 | Up | 0.1164225406 |
| GSE36640 | Down | -0.5178464309 |
| GSE54402 | Down | -0.4384423009 |
| GSE9593 | Down | -0.0972049690 |
| GSE43922 | Up | 0.0539786878 |
| GSE24585 | Up | 0.0097657235 |
| GSE37065 | Up | 0.2595317833 |
| GSE28863_A1 | Up | 0.0095910441 |
| GSE28863_A2 | Down | -0.0026933841 |
| GSE28863_A3 | Up | 0.1316399908 |
| GSE28863_A4 | Up | 0.1032668062 |
| GSE48662 | Up | 0.0622548339 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25002533 | The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates the activation of the Raf/MEK/extracellular signal-regulated kinase (ERK) signal transduction pathway |
| 25002533 | KSR1 disruption in mouse embryo fibroblasts (MEFs) abrogates growth factor-induced ERK activation, H-Ras(V12)-induced replicative senescence, and H-Ras(V12)-induced transformation |
| 25002533 | In this study, we show that KSR1 interacts with caveolin-1 and is responsible for MEK and ERK redistribution to caveolin-1-rich fractions |
| 25002533 | The interaction between KSR1 and caveolin-1 is essential for optimal activation of ERK as a KSR1 mutant unable to interact with caveolin-1 does not efficiently mediate growth factor-induced ERK activation at the early stages of pathway activation |
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