HCSGD entry for IQGAP1
1. General information
| Official gene symbol | IQGAP1 |
|---|---|
| Entrez ID | 8826 |
| Gene full name | IQ motif containing GTPase activating protein 1 |
| Other gene symbols | HUMORFA01 SAR1 p195 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001817 | Regulation of cytokine production | IEA | biological_process |
| GO:0005095 | GTPase inhibitor activity | TAS | molecular_function |
| GO:0005096 | GTPase activator activity | TAS | molecular_function |
| GO:0005099 | Ras GTPase activator activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IPI | molecular_function |
| GO:0005547 | Phosphatidylinositol-3,4,5-trisphosphate binding | IDA | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005874 | Microtubule | IDA | cellular_component |
| GO:0005884 | Actin filament | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005911 | Cell-cell junction | IEA | cellular_component |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0016328 | Lateral plasma membrane | IEA | cellular_component |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0019903 | Protein phosphatase binding | IPI | molecular_function |
| GO:0030054 | Cell junction | IDA | cellular_component |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0030529 | Ribonucleoprotein complex | IEA | cellular_component |
| GO:0031234 | Extrinsic component of cytoplasmic side of plasma membrane | IDA | cellular_component |
| GO:0031252 | Cell leading edge | IEA | cellular_component |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0035305 | Negative regulation of dephosphorylation | IEA | biological_process |
| GO:0036057 | Slit diaphragm | ISS | cellular_component |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0043086 | Negative regulation of catalytic activity | TAS | biological_process |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0043547 | Positive regulation of GTPase activity | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045860 | Positive regulation of protein kinase activity | IEA IMP | biological_process |
| GO:0048365 | Rac GTPase binding | IEA | molecular_function |
| GO:0050796 | Regulation of insulin secretion | TAS | biological_process |
| GO:0071277 | Cellular response to calcium ion | IDA | biological_process |
| GO:0072015 | Glomerular visceral epithelial cell development | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0066512670 | 0.9811034003 | 0.2142641809 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0627836990 |
| GSE13712_SHEAR | Up | 0.4860049086 |
| GSE13712_STATIC | Down | -0.1030083914 |
| GSE19018 | Up | 0.5429773577 |
| GSE19899_A1 | Up | 0.0173952406 |
| GSE19899_A2 | Down | -0.0266839979 |
| PubMed_21979375_A1 | Down | -0.0072775242 |
| PubMed_21979375_A2 | Up | 1.2750649591 |
| GSE35957 | Up | 0.2428079486 |
| GSE36640 | Down | -0.0470785105 |
| GSE54402 | Down | -0.0727269516 |
| GSE9593 | Up | 0.6344727073 |
| GSE43922 | Up | 0.0689226040 |
| GSE24585 | Up | 0.3346903684 |
| GSE37065 | Up | 0.0205238966 |
| GSE28863_A1 | Up | 1.2137242172 |
| GSE28863_A2 | Up | 1.5988544640 |
| GSE28863_A3 | Down | -0.0450580747 |
| GSE28863_A4 | Up | 0.2554713431 |
| GSE48662 | Up | 0.0680444701 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002697 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19843643 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002697 | Luciferase reporter assay//Microarray | Functional MTI | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002697 | Immunoblot//Immunohistochemistry//qRT-PCR//Western blot | Functional MTI | 21196113 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002697 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024313 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026798 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042850 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049578 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23974104 | Drug affinity responsive target stability (DARTS) analysis identified IQ motif-containing factors IQGAP1 and MYH9 as direct binding targets of disulfiram |
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