HCSGD entry for SUCLA2
1. General information
| Official gene symbol | SUCLA2 |
|---|---|
| Entrez ID | 8803 |
| Gene full name | succinate-CoA ligase, ADP-forming, beta subunit |
| Other gene symbols | A-BETA MTDPS5 SCS-betaA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004775 | Succinate-CoA ligase (ADP-forming) activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006099 | Tricarboxylic acid cycle | IEA TAS | biological_process |
| GO:0006104 | Succinyl-CoA metabolic process | IEA TAS | biological_process |
| GO:0006105 | Succinate metabolic process | IEA | biological_process |
| GO:0006781 | Succinyl-CoA pathway | NAS | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9626753543 | 0.1599674063 | 0.9999902473 | 0.7725874702 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0352543707 |
| GSE13712_SHEAR | Up | 0.0836496216 |
| GSE13712_STATIC | Up | 0.1347088980 |
| GSE19018 | Down | -0.2638120598 |
| GSE19899_A1 | Up | 0.0487867694 |
| GSE19899_A2 | Down | -0.1751751214 |
| PubMed_21979375_A1 | Up | 0.0264009142 |
| PubMed_21979375_A2 | Down | -0.3009490052 |
| GSE35957 | Down | -0.0262668135 |
| GSE36640 | Down | -0.1360098292 |
| GSE54402 | Down | -0.2885382129 |
| GSE9593 | Down | -0.3257718167 |
| GSE43922 | Down | -0.0898687180 |
| GSE24585 | Up | 0.2258065731 |
| GSE37065 | Up | 0.0569441173 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.4272981621 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023320 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-1 | MIMAT0000416 | MIRT023695 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028494 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031701 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038843 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
