HCSGD entry for TNFRSF11A

1. General information

Official gene symbolTNFRSF11A
Entrez ID8792
Gene full nametumor necrosis factor receptor superfamily, member 11a, NFKB activator
Other gene symbolsCD265 FEO LOH18CR1 ODFR OFE OPTB7 OSTS PDB2 RANK TRANCER
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001503OssificationIEAbiological_process
GO:0002250Adaptive immune responseIMPbiological_process
GO:0002548Monocyte chemotaxisNASbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0004888Transmembrane signaling receptor activityIDAmolecular_function
GO:0005031Tumor necrosis factor-activated receptor activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0007165Signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0009314Response to radiationIEAbiological_process
GO:0009897External side of plasma membraneIDAcellular_component
GO:0012501Programmed cell deathISSbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0019955Cytokine bindingIPImolecular_function
GO:0030316Osteoclast differentiationIMPbiological_process
GO:0032496Response to lipopolysaccharideISSbiological_process
GO:0033209Tumor necrosis factor-mediated signaling pathwayISSbiological_process
GO:0034097Response to cytokineIMPbiological_process
GO:0034612Response to tumor necrosis factorISSbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingRCAbiological_process
GO:0043507Positive regulation of JUN kinase activityIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048535Lymph node developmentIEAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIDA ISSbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDA IMPbiological_process
GO:0060086Circadian temperature homeostasisISSbiological_process
GO:0060749Mammary gland alveolus developmentIEAbiological_process
GO:0070555Response to interleukin-1ISSbiological_process
GO:0071812Positive regulation of fever generation by positive regulation of prostaglandin secretionISSbiological_process
GO:0071847TNFSF11-mediated signaling pathwayIMPbiological_process
GO:0071848Positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.17654021120.59801595300.82470220051.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1503063532
GSE13712_SHEARUp0.0626883165
GSE13712_STATICUp0.2287214772
GSE19018Up0.0577228493
GSE19899_A1Up0.0924312838
GSE19899_A2Up0.4726738222
PubMed_21979375_A1Up0.5802913189
PubMed_21979375_A2Up0.3663617084
GSE35957Up0.4929582270
GSE36640Up0.1144674057
GSE54402Up0.0738144037
GSE9593Down-0.1421050806
GSE43922Up0.0270150277
GSE24585Down-0.4609296582
GSE37065Down-0.0528111234
GSE28863_A1Down-0.2859714209
GSE28863_A2Down-0.3983418465
GSE28863_A3Up0.2178547731
GSE28863_A4Up0.0801168488
GSE48662Up0.0342033469

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029973MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.