HCSGD entry for PABPC4
1. General information
| Official gene symbol | PABPC4 |
|---|---|
| Entrez ID | 8761 |
| Gene full name | poly(A) binding protein, cytoplasmic 4 (inducible form) |
| Other gene symbols | APP-1 APP1 PABP4 iPABP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006396 | RNA processing | TAS | biological_process |
| GO:0006401 | RNA catabolic process | TAS | biological_process |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008143 | Poly(A) binding | IDA | molecular_function |
| GO:0008266 | Poly(U) RNA binding | IDA | molecular_function |
| GO:0010494 | Cytoplasmic stress granule | IDA | cellular_component |
| GO:0017130 | Poly(C) RNA binding | IDA | molecular_function |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5188677140 | 0.1751606664 | 0.9999902473 | 0.8095529236 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1108825757 |
| GSE13712_SHEAR | Down | -0.4841699969 |
| GSE13712_STATIC | Down | -0.3129264786 |
| GSE19018 | Down | -0.0207211735 |
| GSE19899_A1 | Down | -0.1317388955 |
| GSE19899_A2 | Up | 0.0653669286 |
| PubMed_21979375_A1 | Up | 0.5887876901 |
| PubMed_21979375_A2 | Up | 0.9301508104 |
| GSE35957 | Up | 0.0240093349 |
| GSE36640 | Down | -0.4870075733 |
| GSE54402 | Up | 0.1721325571 |
| GSE9593 | Up | 0.4316228687 |
| GSE43922 | Down | -0.0386432616 |
| GSE24585 | Down | -0.6894960328 |
| GSE37065 | Down | -0.6581495214 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.1859052673 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022926 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024565 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026691 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027746 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031882 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031882 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039627 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044975 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046051 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20943973 | NFX1-123, the longer splice variant of NFX1, interacts with HPV16 E6, as well as cytoplasmic poly(A) binding proteins 1 and 4 (PABPC1 and PABPC4) |
| 20943973 | Although the amount and cellular localization of PABPCs were largely unchanged in cervical cancer cell lines with or without HPV16 and in human foreskin keratinocytes (HFKs) with or without HPV16 E6, knockdown of PABPCs decreased hTERT mRNA and telomerase activity and overexpression of PABPC4 increased these in HPV16 E6-expressing HFKs |
| 20943973 | Additionally, overexpression of PABPC4 and hTERT led to greater growth of cultured HPV16 E6-expressing HFKs |
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