HCSGD entry for ADAM18
1. General information
| Official gene symbol | ADAM18 |
|---|---|
| Entrez ID | 8749 |
| Gene full name | ADAM metallopeptidase domain 18 |
| Other gene symbols | ADAM27 tMDCIII |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0008237 | Metallopeptidase activity | TAS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030154 | Cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6031474108 | 0.8762746362 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1334790532 |
| GSE13712_SHEAR | Up | 0.1022694516 |
| GSE13712_STATIC | Up | 0.0574847649 |
| GSE19018 | Down | -0.0139539023 |
| GSE19899_A1 | Up | 0.2579927034 |
| GSE19899_A2 | Up | 0.2350655469 |
| PubMed_21979375_A1 | Up | 0.2441362218 |
| PubMed_21979375_A2 | Down | -0.1716812834 |
| GSE35957 | Down | -0.0135284896 |
| GSE36640 | Up | 0.0267781418 |
| GSE54402 | Up | 0.0850054381 |
| GSE9593 | Down | -0.0266183858 |
| GSE43922 | Up | 0.0214071659 |
| GSE24585 | Up | 0.1914327141 |
| GSE37065 | Down | -0.1035414372 |
| GSE28863_A1 | Up | 0.0293024789 |
| GSE28863_A2 | Up | 0.0318023507 |
| GSE28863_A3 | Up | 0.1584326930 |
| GSE28863_A4 | Down | -0.0559079920 |
| GSE48662 | Up | 0.0305009460 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029408 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
