HCSGD entry for TNFSF10

1. General information

Official gene symbolTNFSF10
Entrez ID8743
Gene full nametumor necrosis factor (ligand) superfamily, member 10
Other gene symbolsAPO2L Apo-2L CD253 TL2 TRAIL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005102Receptor bindingTASmolecular_function
GO:0005125Cytokine activityIEAmolecular_function
GO:0005164Tumor necrosis factor receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processTASbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008584Male gonad developmentIEAbiological_process
GO:0032868Response to insulinIEAbiological_process
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0090200Positive regulation of release of cytochrome c from mitochondriaIDAbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:2001238Positive regulation of extrinsic apoptotic signaling pathwayIDAbiological_process
GO:2001239Regulation of extrinsic apoptotic signaling pathway in absence of ligandTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04249794840.05675757000.46051197040.4474859707

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0032330246
GSE13712_SHEARDown-1.8071736113
GSE13712_STATICDown-1.0842762281
GSE19018Up0.0662645468
GSE19899_A1Up0.0757783053
GSE19899_A2Down-0.0300549109
PubMed_21979375_A1Down-0.1177185704
PubMed_21979375_A2Down-0.0400032795
GSE35957Down-1.1024466599
GSE36640Up0.5750288708
GSE54402Down-0.6656585014
GSE9593Down-0.2879664393
GSE43922Down-0.6353529445
GSE24585Up0.5754058543
GSE37065Up1.6067344708
GSE28863_A1Up1.3918420040
GSE28863_A2Up1.6405216494
GSE28863_A3Up0.0992457842
GSE28863_A4Down-0.0359319090
GSE48662Up0.1379779893

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-222-3pMIMAT0000279MIRT003756Western blotFunctional MTI18246122
hsa-miR-221-3pMIMAT0000278MIRT003757Western blotFunctional MTI18246122
hsa-miR-98-5pMIMAT0000096MIRT027770MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26152738EXPERIMENTAL DESIGN: We combined treatment with an aurora kinase A inhibitor, MLN8237, with agents that activate death receptors (Apo2L/TRAIL or death receptor 5 agonists) and monitored the ability of this treatment to induce tumor apoptosis and melanoma tumor regression using human cell lines and patient-derived xenograft (PDX) mouse models
26152738Mechanistic analysis showed that the induction of tumor cell senescence in response to the AURKA inhibitor resulted in a decreased display of Apo2L/TRAIL decoy receptors and increased display of one Apo2L/TRAIL receptor (death receptor 5), resulting in enhanced response to death receptor ligand/agonists
26152738Senescent tumor cells exhibited BID-mediated mitochondrial depolarization in response to Apo2L/TRAIL treatment
12473065Apo2Ligand/tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) has been observed to preferentially induce cytopathic effects on transformed/malignant cell types compared with their non-neoplastic counterparts
12473065In this report, two different biologically active preparations of Apo2L/TRAIL, a non-tagged version, NT-Apo2L/TRAIL, and a leucine zipper fusion protein, LZ-Apo2L/TRAIL, were examined for their ability to trigger apoptosis in normal human keratinocytes, and in an immortalized cell line (HaCaT cells)
12473065Similarities between preparations included: an enhanced ability for both Apo2L/TRAIL preparations to kill a greater relative percentage of HaCaT cells compared with keratinocytes; enhanced cytotoxicity towards keratinocytes that had their NF-B activity inhibited; a dependence of both Apo2L/TRAIL preparations on FADD and caspase activation; triggering of the same caspase cascades including caspase 8 and 3; and an ability to induce apoptosis even when HaCaT cells and keratinocytes were transduced to overexpress either Bcl-2 or Bcl-x(L) (survival factors that reduce susceptibility to UV-light-induced apoptosis)
12473065These results indicate that while both preparations of Apo2L/TRAIL possess biological activity, there are important differences as regards their ability to induce apoptosis in normal and immortalized keratinocytes
12473065In addition, it may be possible to utilize these Apo2L/TRAIL preparations for the treatment of various sun-induced skin cancers as they can differentially trigger apoptosis of transformed keratinocytes, or keratinocytes with abnormal NF-kappaB signaling, while sparing adjacent normal keratinocytes
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