HCSGD entry for TNFSF12
1. General information
| Official gene symbol | TNFSF12 |
|---|---|
| Entrez ID | 8742 |
| Gene full name | tumor necrosis factor (ligand) superfamily, member 12 |
| Other gene symbols | APO3L DR3LG TWEAK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0001938 | Positive regulation of endothelial cell proliferation | TAS | biological_process |
| GO:0005102 | Receptor binding | TAS | molecular_function |
| GO:0005125 | Cytokine activity | IEA TAS | molecular_function |
| GO:0005164 | Tumor necrosis factor receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | IEA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0043542 | Endothelial cell migration | TAS | biological_process |
| GO:0045766 | Positive regulation of angiogenesis | TAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
| GO:2001238 | Positive regulation of extrinsic apoptotic signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0006848106 | 0.9999239695 | 0.0751037500 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.6236999515 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-17-5p | MIMAT0000070 | MIRT004681 | Luciferase reporter assay | Functional MTI | 19478946 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024478 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051945 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
