HCSGD entry for TNFSF14

1. General information

Official gene symbolTNFSF14
Entrez ID8740
Gene full nametumor necrosis factor (ligand) superfamily, member 14
Other gene symbolsCD258 HVEML LIGHT LTg TR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005102Receptor bindingIPImolecular_function
GO:0005125Cytokine activityIEAmolecular_function
GO:0005164Tumor necrosis factor receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0008588Release of cytoplasmic sequestered NF-kappaBIDAbiological_process
GO:0010466Negative regulation of peptidase activityIDAbiological_process
GO:0010820Positive regulation of T cell chemotaxisIEAbiological_process
GO:0010951Negative regulation of endopeptidase activityIDAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0031295T cell costimulationIEAbiological_process
GO:0042098T cell proliferationNASbiological_process
GO:0042110T cell activationNASbiological_process
GO:0043027Cysteine-type endopeptidase inhibitor activity involved in apoptotic processIDAmolecular_function
GO:0043029T cell homeostasisNASbiological_process
GO:0043086Negative regulation of catalytic activityIDAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0043281Regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0052547Regulation of peptidase activityIDAbiological_process
GO:0052548Regulation of endopeptidase activityIDAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.43627689680.89194742220.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0743207922
GSE13712_SHEARUp0.0029605816
GSE13712_STATICDown-0.0058249846
GSE19018Up0.1632872143
GSE19899_A1Up0.1510086671
GSE19899_A2Up0.2236510848
PubMed_21979375_A1Up0.0721688061
PubMed_21979375_A2Down-0.0154177289
GSE35957Up0.1249667907
GSE36640Up0.2227428206
GSE54402Up0.0459244620
GSE9593Down-0.0099208985
GSE43922Up0.1080606489
GSE24585Up0.0397429957
GSE37065Down-0.0698741510
GSE28863_A1Down-0.1671129471
GSE28863_A2Down-0.2989142604
GSE28863_A3Up0.1935869809
GSE28863_A4Up0.1783983647
GSE48662Down-0.0376439010

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.